Fast-dissolving co-crystalline lactose
A technology for lactose and co-crystals is applied in the preparation of nutritional compositions comprising lactose/calcium salt co-crystals, the lactose/calcium salt co-crystals are used for preparing nutritional compositions, and the field of preparing lactose/calcium salt co-crystals can solve the problem of lactose dissolution. behavior has not been studied, etc.
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 2
[0158] Preparation of the seed crystal (lactose / calcium chloride heptahydrate co-crystal) used in Example 2:
[0159] At 40-65 °C and 300 rpm, 50.0 g of lactose monohydrate and 50.0 g of calcium chloride dihydrate were added successively to 75.0 g of water within 20 minutes. Allow the solution to cool to 15-35°C and continue stirring until crystals start to precipitate.
[0160] The suspension was filtered and the separated crystals were washed with cold (8-10°C) ethanol at room temperature. The isolated product was dried under vacuum at 15-45°C for 1-3 hours and at 15-25°C for 36-60 hours without vacuum.
[0161] result:
[0162] Co-crystallized lactose / calcium chloride 7H is obtained in the form of white powder 2 O.
[0163] Example 2 :
[0164] Preparation of Lactose / Calcium Chloride Co-Crystals Using Seed Crystals:
[0165] 100.0 g of calcium chloride dihydrate and 100.0 g of lactose monohydrate were gradually added to 166.0 g of water. The dissolution is exotherm...
Embodiment 3
[0169] Measure 2 g lactose / CaCl by refraction over a period of 0 to 100 seconds at room temperature while the solution is agitated 2 ·7H 2 O co-crystal in water (◆), compared to 1.24 g of pure lactose monohydrate in water (■), 1.24 g of lactose monohydrate in 0.52 g of calcium chloride solution (▲), and 1.24 g of lactose monohydrate and Dissolution kinetics of a physical mixture of 0.52 g calcium chloride dihydrate in water (×). The particle sizes of the corresponding solids (60-90 μm) were comparable.
[0170] result:
[0171] figure 1 showed that, within 20 seconds, about 85% of the co-crystallized material i.e. lactose / CaCl 2 ·7H 2 The O co-crystal dissolves in water, while at the same time only about 20% of lactose monohydrate dissolves in water. Similarly, a significantly lower amount of lactose monohydrate was dissolved in the calcium chloride solution compared to the co-crystallized material, ie about 30%. In a physical mixture of lactose and calcium chloride, abou...
Embodiment 4
[0173] Determination of individual α-lactose / CaCl compared to α-lactose monohydrate (▲) 2 ·7H 2 Dissolution kinetics of the O co-crystal (■). Dissolution kinetics were measured over a period of 0 to 36 seconds at room temperature and without agitation.
[0174] result:
[0175] Such as figure 2 Shown, Lactose / CaCl 2 ·7H 2 The complete dissolution of the O co-crystal took about 2.5 seconds, while that of lactose monohydrate required about 36 seconds. Therefore, lactose / CaCl 2 ·7H 2 The O co-crystal dissolves approximately 14 to 15 times faster than lactose monohydrate.
PUM
Login to View More Abstract
Description
Claims
Application Information
Login to View More