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Establishment and Detection Method of HPLC Fingerprint of Jinbei Oral Liquid

A technology of Jinbei oral liquid and fingerprint spectrum is applied in the field of establishment and detection of HPLC fingerprint of Jinbei oral liquid, which can solve the problems of complex chemical composition, many flavors of Jinbei oral liquid, and difficulty in effectively controlling the internal quality of drugs, and achieves enhanced Specific identification and multi-ingredient effects

Active Publication Date: 2020-03-17
山东宏济堂制药集团股份有限公司
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

[0003] Jinbei Oral Liquid has many medicinal flavors and complex chemical components, and the existing quality standards are difficult to effectively control the inherent quality of drugs

Method used

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  • Establishment and Detection Method of HPLC Fingerprint of Jinbei Oral Liquid
  • Establishment and Detection Method of HPLC Fingerprint of Jinbei Oral Liquid
  • Establishment and Detection Method of HPLC Fingerprint of Jinbei Oral Liquid

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Embodiment 1

[0043] 1. Instruments and reagents

[0044] 1.1 Instruments Acchrom S6000 high-performance liquid chromatography; one hundred thousandth electronic balance, Mettler-Toledo Instruments (Shanghai) Co., Ltd.; KQ-300DE CNC ultrasonic cleaner.

[0045] 1.2 Reagents Chlorogenic acid (batch number 110753-201716), baicalin (batch number 110715-201619), and salvianolic acid B (batch number 111562-201313) were purchased from China National Institutes for Food and Drug Control.

[0046] Jinbei Oral Liquid was developed by Shandong Hongjitang Pharmaceutical Group, batch numbers 1706001-1706003, 1707001-1707003, 1708001-1708004.

[0047] Methanol is chromatographically pure and analytically pure; acetonitrile is chromatographically pure; phosphoric acid is chromatographically pure; water is ultrapure water.

[0048] 2. Methods and Results

[0049] 2.1. Chromatographic conditions

[0050] Inertsil ODS-3C18 chromatographic column (4.6mm*250mm, 5μm); column temperature 35°C; mobile phase a...

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Abstract

The invention discloses HPLC fingerprint establishment and detection methods of a Jinbei oral liquid. A HPLC method for simultaneously determining 3 active ingredients is established finally with maincomponents including chlorogenic acid, baicalin and salvianolic acid B of flos lonicerae, radix scutellariae and radix salviae miltiorrhizae as index components according to the physicochemical properties of components contained in the Jinbei oral liquid in combination with sovereign, minister, assistant and courier and the requirement of Chinese Pharmacopoeia in 2015 version for quantitative determination of all medicinal materials, Jinbei oral liquid fingerprint research is conducted, and reference and evidence are provided for quality control of the Jinbei oral liquid.

Description

technical field [0001] The invention relates to the technical field of drug detection, in particular to a method for establishing and detecting HPLC fingerprints of Jinbei oral liquid. Background technique [0002] Jinbei Oral Liquid is a traditional Chinese medicine compound preparation composed of 12 medicinal materials including astragalus, Codonopsis pilosula, Adenophora, Salvia miltiorrhiza, Angelica, Chuanxiong, honeysuckle, Forsythia, Scutellaria baicalensis, Chuan Fritillaria, Pinellia chinensis, and licorice. More than 200 cases of its prescription have been clinically verified for symptoms such as shortness of breath, dyspnea, dry cough with less phlegm, chest tightness and chest pain, cyanosis or low-grade fever caused by qualitative lung diseases, and the curative effect is definite. [0003] Jinbei oral liquid has many medicinal flavors and complex chemical components, and the existing quality standards are difficult to effectively control the internal quality o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06
Inventor 张京华张爱均杨万青宋骁孟兆青李秀凤王卫平
Owner 山东宏济堂制药集团股份有限公司