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Gold/iron carbide heterogeneous nanometer particle and preparation and application thereof

A gold nanoparticle and nanoparticle technology, which is applied in the field of preparation and application of gold/iron carbide heterogeneous nanoparticles, can solve the problems of difficult application of chemical structure and easy detachment of components.

Active Publication Date: 2018-01-19
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Most of the reported multimodal imaging probes are combined by connecting or wrapping a variety of imaging contrast probes. This method has a great risk that the components are easy to fall off.
Others are difficult to implement in vivo applications because of their unstable chemical structures

Method used

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  • Gold/iron carbide heterogeneous nanometer particle and preparation and application thereof
  • Gold/iron carbide heterogeneous nanometer particle and preparation and application thereof
  • Gold/iron carbide heterogeneous nanometer particle and preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Example 1 Probe for multimodal imaging

[0064] 1. The preparation process of the multimodal imaging probe:

[0065] 1) Au-Fe 2 Synthesis of C heterogeneous nanoparticles:

[0066] A. Preparation of 4nm Au nanoparticles

[0067] Add 98mg HAuCl to the 100mL four-necked bottle 4 ·3H 2 O, 10mL n-hexane, 10mL oleylamine (OAm), dissolve and mix well. Place the four-neck bottle in a water tank at 5°C. The four-necked bottle was sealed, and protected by Ar, and kept stirring. Weigh 16 mg of tert-butylamine-borane (TBAB) and dissolve in 1 mL of n-hexane and 1 mL of oleylamine. Add the TBAB solution into the bottle with a syringe, keep the temperature constant for 2 hours, then stop the reaction, and centrifuge at 10,000 rpm for 10 minutes. The centrifuged Au nanoparticles were redispersed in 10 mL cyclohexane for storage.

[0068] B. Preparation of 9nm Au nanoparticles by seed growth method

[0069] Weigh 100mg HAuCl 4 ·3H 2 O was added to the four-neck flask, and 1...

Embodiment 2

[0087] Example 2 Photothermal Therapy Probe Guided by Photoacoustic Imaging

[0088] 1. Probe preparation process:

[0089] Photoacoustic imaging-guided photothermotherapy probes (i.e., Au-Fe 2 C-Z HER2:342 ) preparation: 100μL 1mM Z HER2:342 The solution was dissolved in 2 mL of phosphate buffer (PBS, pH=7.4), and 5 mg of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC HCl) and 5 mg of N-hydroxy Sulfosuccinimide (NHS-sulfo), stirred and activated for 1h, then added 25mg modified DSPE-PEG-NH 2 Obtained Au-Fe 2 C-PEG nanoparticles, continue to stir for 4h. Centrifuge at 20000rpm for 20min to collect the product, and dialyze for 24h to remove unreacted Z HER2:342 and EDC HCl, NHS-sulfo, the photoacoustic imaging-guided photothermotherapy probe Au-Fe can be obtained 2 C-Z HER2:342 , the multimodal imaging is magnetic resonance imaging and photoacoustic imaging.

[0090] 2. Au-Fe 2 C-Z HER2:342 The relative performance of the probe

[0091] 1) In vitro...

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Abstract

The invention discloses a gold / iron carbide heterogeneous nanometer particle and a preparation method and application thereof. The gold / iron carbide heterogeneous nanometer particle is of a janus heterogeneous structure and can serve as a bio-imaging probe, functional modification is conducted through the bio-imaging probe, and application of a photo-thermal treatment probe under guidance of multimode imaging (nuclear magnetic resonance imaging / multispectral photoacoustic tomography imaging / computerized tomography imaging) is achieved. The probe targets tumor cells in a specificity mode, and selective photo-thermal killing for the specific tumor cells can be achieved; and at the same time, due to optical and magnetic properties of the probe, the probe can serve as a contrast agent of multimode imaging to monitor the tumor therapeutic effect.

Description

technical field [0001] The present invention relates to the preparation and application of a gold / iron carbide heterogeneous nanoparticle, in particular to a gold / iron carbide heterogeneous nanoparticle guided by multimodal imaging (nuclear magnetic resonance imaging / multispectral photoacoustic tomography / Electron computed tomography (CT) imaging-guided photothermia. Background technique [0002] In recent years, precision therapy has become the focus of everyone's attention. It includes accurate diagnosis of diseases, accurate treatment, and real-time monitoring before and after treatment, so as to improve the effectiveness of disease diagnosis, treatment and prevention. Nanotherapeutics offers a promising avenue for precision therapy because it can combine diagnostics and therapeutics using nanoplatforms. Compared with traditional tumor treatment methods, photothermal therapy can efficiently kill tumor cells while minimizing damage to normal cells. As a minimally invasi...

Claims

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Application Information

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IPC IPC(8): A61K49/00A61K49/18A61K49/22A61K49/04A61K41/00A61P35/00
Inventor 侯仰龙鞠艳敏
Owner PEKING UNIV
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