264 results about "Probe target" patented technology

A nonlinear optical technique, such as second or third harmonic or sum or difference frequency generation, is used to detect binding interactions, or the degree or extent of binding, that comprise a conformational change. In one aspect of the present invention, the nonlinear optical technique detects a conformational change in a probe due to target binding. In another aspect of the invention, the nonlinear optical technique screens candidate probes by detecting a conformational change due to a probe-target interaction. In another aspect of the invention, the nonlinear optical technique screens candidate modulators of a probe-target interaction by detecting a conformational change in the presence of the modulator.

A technique manages targets to which probe packets are sent from a source of a computer network. The novel target management technique dynamically selects an optimal set of valid targets for a particular (monitored) prefix of the computer network. Specifically, one or more targets are selected from a pool of possible learned and configured targets to be used as representatives of the monitored prefix. Probe packets are sent from the source to the selected targets for the duration of an evaluation period. Targets that do not respond to the probe packets during the evaluation period are invalid and deselected, and if available, an unused target is selected from the pool of possible targets to replace each non-responding target for a next evaluation period. Invalid learned targets are discarded, while invalid configured targets are returned to the pool of possible targets for potential re-selection in a later evaluation period.

An assay article for detection biopolymers contained in a sample is described. The assay article includes a substrate and a biopolymer directly adsorbed on the surface of the substrate. A plurality of biopolymers may be adsorbed on the surface of the substrate to form an array. Also disclosed is a method of making the assay article. In the preferred method, an aminated polypropylene substrate is used. A biopolymer is contacted with the aminated substrate under a condition sufficient for direct adsorption of the biopolymer on the surface of the substrate. A method of detecting a target biopolymer contained in a sample is also disclosed. In this method, a substrate is contacted with either a probe or target biopolymer under a condition sufficient for a direct adsorption of either the probe or target biopolymer on the substrate to form a probe assay article or a target assay article. Then, the probe assay article is contacted with the target biopolymer, or the target assay article is contacted with the probe biopolymer under a condition that allows the formation of a probe-target complex. Finally, the complex is detected and the presence of the complex is used as a measurement for the presence or the amount of the biopolymer target contained in the sample.

A microfluidic device for simultaneous detection of multiple conditions in a patient, the microfluidic device having an inlet for receiving a sample of biological material drawn from the patient, a microsystems technologies (MST) layer with a detection section having an array of probes for reaction with target molecules in the sample to form probe-target complexes, the target molecules being indicative of medical conditions in the patient, and, a photosensor for detecting the probe-target complexes, wherein, the array of probes has more than 1000 probes.

A flaw Z with a long probing length inside a probing target is allowed to be probed. The waves other than the probing target waves are removed or reduced, so that the individual difference in the sizing result due to the ability of the measuring personnel is eliminated to improve the precision of the probing. A transmission probe 31 and a receiving probe 32 for transmitting and receiving a wide band ultrasonic wave are included. Each time the positions of the probes 31 and 32 are moved, a received wave Gj(t) is obtained. From a spectrum Fj(f) corresponding to the received wave Gj(t), a narrowband spectrum FAj(f) is extracted. A component wave GAj(t) corresponding to the narrow band spectrum FAj(f) is obtained by inverse Fourier transformation. The component wave GAj(t) is provided for a comparative display using a predetermined sizing coefficient. The position of a flaw Z is determined inside a probing target 30 right below the line segment connecting the centers of the transmission probe 31 and the receiving probe 32, based on at which of the measurement points a wave is generated on the comparative display screen.