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Application of a core-shell nanoparticle

A nanoparticle, core-shell type technology, applied in the application field of composite nanoparticles, to achieve the effect of improving optical and magnetic properties, improving biocompatibility, and low cost

Inactive Publication Date: 2011-11-30
CHANGCHUN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The present invention uses water-based quantum dots to wrap gold nanorods layer by layer to prepare composite nanoparticles. This invention has not been reported

Method used

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  • Application of a core-shell nanoparticle
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  • Application of a core-shell nanoparticle

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Embodiment 1

[0028] Embodiment 1 A method for preparing core-shell nanoparticles, the steps and conditions are as follows:

[0029] Described a kind of core-shell type nanoparticle, see appendix figure 1, the core-shell nanoparticle is that the core material is gold nanorods; the middle layer is silicon dioxide and surface receptors; the outer shell is a coupling body of water-based CdTe quantum dots and biomolecules; the length of the gold nanorods is 50nm, the aspect ratio is 2-3:1; the thickness of the middle layer of silicon dioxide wrapped gold nanorods is 2-10nm, the distance between gold nanorods and silicon dioxide is controlled at 3-5nm; the middle layer introduces The surface receptor is 3-cyanobenzenesulfonyl chloride, parallel mercaptoaminobenzene (pABT), isothiocyanate (RBITC) or 2-naphthalenesulfonol (2-NAT); Combined with gold nanorods; the conjugated biomolecules include immunoglobulin IgG or 8 antibody (anti-CEA8).

[0030] (1) Core material gold nanorods, prepared by se...

Embodiment 2

[0036] Embodiment 2 A method for preparing core-shell nanoparticles, the volume ratio of the gold nanorod solution described in step (2) to the described alcohol ethyl silicate solution is 1: 0.3; Reaction is 50 seconds, and the surface acceptor that intermediate layer introduces is parallel mercaptoaminobenzene; The described reaction time of step (4) is 2 hours; Under the described normal temperature of step (5), react 40 minutes; All the other are with embodiment 1 .

Embodiment 3

[0037] Embodiment 3 A method for preparing core-shell nanoparticles, the volume ratio of the gold nanorod solution described in step (2) to the described alcohol ethyl silicate solution is 1: 0.4; Reaction is 60 seconds, and the surface acceptor that middle layer introduces is isothiocyanate; The described reaction time of step (4) is 6 hours; Under the described normal temperature of step (5), react 45 minutes; All the other are with embodiment 1.

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Abstract

The invention provides an application of core-shell nanoparticles for preparing biological imaging agents, molecular biological probes and targeted drug-carrying carriers. The core-shell nanoparticle is that the inner core material is gold nanorod; the middle layer is silicon dioxide and surface acceptor; the outer shell is a coupling body of water-based CdTe quantum dots and biomolecules. The core-shell nanoparticle has low toxicity and low cost, solves the problem of water solubility of the nanoparticle, and improves the biocompatibility of the composite nanoparticle. The core-shell nanoparticles have strong fluorescence characteristics, and the surface receptors have spectral signals, and the fluorescence signals are observed through the biological imaging system to obtain the information of the lesion. Utilizing the strong fluorescent properties of the core-shell nanoparticles, they can be combined with cells in living organisms as biological probes for early diagnosis of diseases. The complex of drug and core-shell nanoparticles will successfully reside on the surface of cancer cells, and the drug will reach the cancer cells to achieve therapeutic effect.

Description

technical field [0001] The invention belongs to the application of composite nanoparticles, in particular to the application of core-shell nanoparticles. Background technique [0002] Nanoparticles refer to tiny particles with a particle size ranging from 1 to 100 nanometers. Due to the unique magnetic, electrical, and optical properties and functions of substances at this scale, the research and application of nanoparticles have developed rapidly. Especially in biological imaging and detection, it is more widely used. In order to achieve biological applications as fluorescent labels, it is very necessary to prepare water-soluble, stable and dispersible semiconductor quantum dots. [0003] Gold nanorods have excellent properties such as high stability and low toxicity. The excitation spectrum of II-VI compound semiconductor quantum dots is in the visible light range, and the wavelength can be continuously distributed. It can simultaneously excite different sizes under the sa...

Claims

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Application Information

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IPC IPC(8): A61K49/00A61K47/02A61K47/04A61K47/20
Inventor 刘丽炜蔡红星胡思怡李钰苗馨卉张喜和
Owner CHANGCHUN UNIV OF SCI & TECH
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