Inspection system, inspection device, and inspection method
An inspection system and inspection device technology, applied in the direction of measuring devices, biochemical cleaning devices, biochemical equipment and methods, etc., can solve the problems of difficult detection of biomarkers, omission of iPS cell characteristic quantities, etc., achieve labor suppression and realize analysis costs , to achieve the effect of reliability
Active Publication Date: 2018-01-19
HITACHI LTD
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Problems solved by technology
Furthermore, in recent years, it has been found that cancer stem cells are estimated to exist in a ratio of several percent or less in the diversity of these cancer cells, and it is difficult to detect biomarkers possessed by such cancer stem cells.
In addition, as another example, in the case of analyzing and evaluating iPS cells with an induction rate of several % to 20%, when the analysis is performed by the conventional method using the average value of the sample, there may be cases where the iPS cells with a low ratio are present. Risk of omission of characteristic quantities of cells
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[0025] Hereinafter, an example of an embodiment of the present invention will be described with reference to the drawings. However, this embodiment is merely an example for realizing the present invention, and does not limit the present invention. In addition, in this example, the gene expression analysis using a next-generation sequencer is taken as an example, but the case where other methods such as quantitative PCR and microarray are used as the gene detection method is also included in the present invention. Similarly, gene expression analysis is also an example of biomarkers derived from individual cells, including the case where the detection target is nucleic acid molecules such as miRNA and genomic DNA, proteins, or cellular metabolites.
[0026] In this embodiment, the object to be tested is a sample from a specific individual who is an inspection object. Even if it comes from the same individual, if the sample collection site, sample collection timing, sample collec...
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A characteristic value of a plurality of biological samples is optically acquired from a specimen, the characteristic value is compared with prior inspection information for the same specimen, and onthe basis of the comparative results, an index is calculated for determining whether to carry out a continuation of processing to genetic analysis of the biological sample or to readjust the sample from the same specimen. Thus, in analysis of a single cell or analysis of a small numbered group of cells, the cost of analysis, time for analysis, and effort can be restrained while suitably selectinginspection samples and securing validity, thereby detecting biomarkers with greater reliability.
Description
technical field [0001] The present invention relates to the examination of biological samples. In particular, it involves analysis of biological tissues including gene analysis, cell function analysis, etc., as well as disease diagnosis, drug development, and the like. Background technique [0002] Biomarkers such as the type of protein or mRNA, the amount thereof, or the variation of genomic genes are important indicators for characterizing individuals and tissues. For example, in the diagnosis of cancer, the mainstream of diagnosis is the observation of cells by pathologists, and the remarkable feature of using these biomarkers is that they can provide objective indicators and detect subtle features that cannot be detected in conventional image diagnosis. Changes, such as local changes in protein molecules and nucleic acid molecules that cannot be identified by cell images alone. [0003] In particular, diagnosis using these biomarkers is important for effect determinati...
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IPC IPC(8): C12M1/34C12Q1/02G16B30/00G16B50/00
CPCC12M1/34G01N1/2813G01N1/31G01N35/00603G01N2035/0094G01N2015/1006G16B30/00G16B50/00G01N15/1433G01N1/00G16H10/40C12Q1/02C40B40/06
Inventor 横井崇秀白井正敬
Owner HITACHI LTD