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External traditional Chinese medicine composition for treating tetter as well as preparation method and application thereof

A composition and technology of traditional Chinese medicine, which are applied in the field of traditional Chinese medicine composition and its preparation, and the traditional Chinese medicine composition for external treatment of skin rash and its preparation field, which can solve the problems that the treatment cannot be carried out normally, the effect of tumor treatment is affected, and the effect is not obvious.

Active Publication Date: 2018-01-23
常州桐树生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Acne / acne-like rash not only affects the quality of life of patients, but also may lead to the failure of normal treatment, seriously affecting the therapeutic effect of tumors
Acne / acneoid rash limits the application of EGFRIs to some extent
Western medicine often uses antibiotics, external hormones and other methods of treatment, the effect is not very obvious

Method used

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  • External traditional Chinese medicine composition for treating tetter as well as preparation method and application thereof
  • External traditional Chinese medicine composition for treating tetter as well as preparation method and application thereof
  • External traditional Chinese medicine composition for treating tetter as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0051] Clinical effect of experimental example 1 composition of the present invention on EGFRIs related erythra

[0052] From January 2013 to January 2016, a total of 273 patients with EGFRIs-related rash were enrolled, and a total of 251 patients completed clinical observation. All patients were diagnosed with malignant tumors in the Oncology Department of the China-Japan Friendship Hospital, the Oncology Department of the PLA General Hospital, the Oncology Department of Beijing Chest Hospital, and the Oncology Department of Chaoyang Hospital. Among them, 92 cases were enrolled in the experimental group of China-Japan Friendship Hospital, and 35 cases were enrolled in the control group; 54 cases were enrolled in the experimental group of the PLA General Hospital, and 18 cases were enrolled in the control group; 15 cases in the group; 6 cases were enrolled in Chaoyang Hospital, and 2 cases were enrolled in the control group.

[0053] 1. Diagnostic criteria:

[0054] Patients...

Embodiment 1

[0107] Prescription: Scutellaria baicalensis 20g, purslane 30g, white moss bark 30g, flavescens 20g, dandelion 30g;

[0108] The content of baicalin in the Scutellaria baicalensis is 2.5%, the total flavonoid content of purslane in purslane is 2%, the total flavonoid content in white moss bark is 2%, the content of matrine in Sophora flavescens is 2%, The content of total flavonoids in dandelion is 1.8%. The content determination methods of the above components were determined according to the content determination methods under the items of Scutellaria baicalensis, purslane, white moss bark, sophora flavescens and dandelion in the 2015 edition of the Chinese Pharmacopoeia.

[0109] Preparation method: Take the raw material according to the proportion, decoct it twice, combine the extracts, filter, concentrate under reduced pressure to a density of 1.10 (60°C), centrifuge at a high speed, and take the supernatant; according to the supernatant: glycerol: density = 2.2 : Add ex...

Embodiment 2

[0113] Prescription: Scutellaria baicalensis 25g, purslane 40g, white moss bark 35g, flavescens 30g, dandelion 35g;

[0114] Preparation method: take the raw material drug in proportion, extract twice with 50% ethanol under reflux, combine the extracts, filter, recover ethanol, add water to dissolve, concentrate under reduced pressure to a density of 1.10 (60°C), centrifuge at a high speed, and take the supernatant; according to the above Serum: Glycerin: Density = 2.2:1:2, adding excipients to make external preparations.

[0115] Usage: Apply directly to the rash area or make a mask and stick it on the face.

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Abstract

The invention provides an external traditional Chinese medicine composition for treating tetter. The traditional Chinese medicine composition is prepared from the following active pharmaceutical ingredients in parts by weight: 10 to 50 parts of radix scutellariae, 10 to 60 parts of herba portulacae, 10 to 60 parts of cortex dictamni, 10 to 50 parts of radix sophorae flavescentis and 10 to 60 partsof herba taraxaci. The traditional Chinese medicine composition has the obvious effect in aspects of relieving EGFRIs ((epidermal growth factor receptor inhibitors) relevant acne-like tetter and thepruritus degree; no obvious untoward effects exist.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and its preparation method and application, in particular to an external Chinese medicinal composition for treating skin rashes, its preparation method and application, and belongs to the technical field of traditional Chinese medicine. Background technique [0002] In recent years, the clinical application of tumor targeted therapy has been increasing year by year, and its therapeutic effect is also increasing. It will soon become a promising tumor treatment method in the 21st century. Epidermal growth factor receptor inhibitors (EGFRIs) are the most widely used clinically at present. These drugs are favored by doctors and patients for their outstanding clinical efficacy. However, its adverse reactions have various manifestations, among which rash (mainly acne / acneoid rash) is the most common. Acne / acne-like rash not only affects the quality of life of patients, but also may lead to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/75A61P17/00A61P17/04
CPCA61K9/0014A61K36/185A61K36/288A61K36/489A61K36/539A61K36/75A61K47/10A61K2236/33A61K2236/331A61K2236/333A61K2300/00
Inventor 崔慧娟王巍
Owner 常州桐树生物科技有限公司
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