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Antibacterial compounds

A compound and composition technology, applied in the field of salicylamide compounds and compositions thereof, can solve the problems of not considering the direct toxic effect of niclosamide, not considering the possible effect of drug efflux and the like

Inactive Publication Date: 2018-01-26
VICTORIA LINK LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the authors did not consider the direct toxic effects of niclosamide, nor the possible role of drug efflux in defense cells against niclosamide, and based on the authors' data, niclosamide appears to be only marginally Effectively inhibits quorum sensing at molar concentrations or higher, suggesting that the drug is indeed transported out of the cell

Method used

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  • Antibacterial compounds
  • Antibacterial compounds
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Embodiment

[0269] The present invention is further described with reference to the following examples. It should be understood that the invention as claimed is not limited in any way by these examples.

[0270] Generation of E. coli strains

[0271] Disruption of PCR amplification was used by the Red recombinase method (Datsenko, K.A. and Wanner, B.L. (2000). One-stepin activation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc Natl Acad Sci USA 97:6640-6645. The cassette generates deletion strains by in-frame deletion. PCR primers for disruption cassette amplification and overlap PCR are in Figure 17 described in. E. coli strain 7KO was derived from E. coli W3110 by deletion of the native nfsA, nfsB, azoR, nemA, yieF, ycaK and mdaB genes. E. coli strain 7KOΔtolC was derived from 7KO by deletion of the native tolC gene. The E. coli strain 7KOΔtolC (DE3) with an integrated λDE3 prophage allowing expression via induction of T7 RNA polymerase was derived from 7K...

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Abstract

The present invention relates to salicylamide compounds and compositions thereof effective in targeting growth of bacteria. The compounds and compositions of the present invention are particularly useful in, for example, the prevention or treatment of bacterial infection and the prevention, reduction or elimination of biofilm formation.

Description

technical field [0001] The present invention relates to salicylamide compounds and compositions thereof effective in preventing or treating bacterial infections caused by Gram-positive bacteria. The present invention further relates to salicylamide compounds in combination with efflux pump inhibitors effective in preventing or treating bacterial infections caused by Gram-negative bacteria, and compositions thereof. Background technique [0002] It is generally expected that the rise of multi-resistant bacteria will be the biggest health problem facing mankind in the 21st century (Boucher, H.W., Talbot, G.H., Bradley, J.S., Edwards, J.E., Gilbert, D., Rice, L.B., Scheldt, M., Spellberg, B. and Bartlett, J. (2009). Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America. Clinical Infectious Diseases 48(1):1-12; Piddock, L.J. (2012). The crisis of no new antibiotics--what is the wayforward? Lancet Infect Dis. 12(3):249-53). Clinicians are alre...

Claims

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Application Information

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IPC IPC(8): A61K31/609A61K48/00A61P31/04
CPCA61K31/426A61K31/609A61K45/06A61P31/04A61P43/00Y02A50/30A61K31/167A61K31/4015
Inventor J·N·科帕D·F·阿克利
Owner VICTORIA LINK LTD
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