PH-sensitive magnetic targeting hydrogel drug beads as well as preparation method and application thereof

Abstract

The invention discloses pH-sensitive magnetic targeting hydrogel drug beads as well as a preparation method and an application thereof. The pH-sensitive magnetic targeting hydrogel drug beads are prepared after chitosan, polyvinyl alcohol, Fe3O4 nanoparticles and antitumor drug methotrexate are fully mixed and subjected to NaOH aqueous solution gelling. The pH-sensitive magnetic targeting hydrogeldrug bead preparation process is simple, low in cost, green and environmentally friendly, the prepared hydrogel drug beads have excellent biocompatibility, and the Fe3O4 nanoparticles can endow the drug beads with good magnetic targeting performance, so that the drug beads fully gather in focus areas under the guide of external magnetic fields. The prepared pH-sensitive magnetic targeting hydrogel drug beads have excellent magnetic response performance and drug slow-release performance and have great application potentials in the targeted tumor therapy field.

Description

technical field [0001] The invention relates to a pH-sensitive magnetic targeting hydrogel medicinal bead, a preparation method and application thereof, and belongs to the technical field of material preparation. Background technique [0002] Methotrexate is one of the well-known antineoplastic drugs, which can treat malignant tumors such as head and neck cancer, breast cancer, skin cancer, and lung cancer. Methotrexate has a very short plasma half-life and a high efflux rate, requiring high doses of methotrexate for treatment. In addition, when the traditional methotrexate drug is used, the drug cannot fully reach the tumor site, but spreads all over the body, causing toxic and side effects on normal tissues, which limits its clinical application. Delivering anti-tumor drugs to the lesion site through nano-carriers, adjusting drug release according to the nature and strength of a certain stimulus-sensitive signal in the external environment can achieve the purpose of local...

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Problems solved by technology

Chinese patent 201410054357.8 discloses a methotrexate-chitosan temperature-sensitive gel and its application. The preparation process requires the use of pH regulators, solubilizers and isotonic regulators, etc., and continuous ice bath stirring is required. The preparation cost is high and the conditions are high. Harsh, in addition, the methotrexate-chitosan thermosensitive gel of the invention does not effectively target the specificity of the tumor microenvironment, that is, the gel drug delivery system does not have pH sensitivity and targeting, and cannot effectively act on the lesion site. Targeted therapy that cannot be applied to tumors

Shao Xue et al. prepared polyvinyl alcohol / chitosan composite hydrogel with interpenetrating network structure as a carrier of chloramphenicol by cyclic freezing-thawing method combined with genipin cross-linking method. However, the preparation of the composite hydrogel The process is cumbersome and the cost is high, and the obtained hydrogel does not have a definite visual appearance. In the process of drug release, it does not have targeting performance and cannot release the drug to the lesion in a targeted manner (Shao Xue et al. pH sensitive type Swelling and Drug Loading and Release Properties of Polyvinyl Alcohol / Chitosan Interpenetrating Network Hydrogel. Journal of Southwest University for Nationalities, 2015, 582-587.)

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