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Satellite-like UCGM nanocomposite material and preparation method thereof

A nano-composite material and satellite-shaped technology, applied in the field of biomaterial research, can solve the problem of lack of effective treatment for deep tumors, and achieve the effects of great biological application prospects, good biological affinity, and increased permeability

Inactive Publication Date: 2020-04-17
南京大学深圳研究院
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The above experiments have improved the treatment effect to a certain extent, but there is no effective treatment for deep tumors.

Method used

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  • Satellite-like UCGM nanocomposite material and preparation method thereof
  • Satellite-like UCGM nanocomposite material and preparation method thereof
  • Satellite-like UCGM nanocomposite material and preparation method thereof

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preparation example Construction

[0022] A method for preparing a satellite-shaped UCGM nanocomposite comprises the following steps:

[0023] (1) Synthesis of UCNPs: Take 1-2mmol gadolinium trifluoroacetate, 0.1-0.2mmol ytterbium trifluoroacetate and 0.05-0.1mmol thulium trifluoroacetate and add to 3-4mL oleic acid, 3-4mL oleylamine and 7-10mL ten In a mixed solvent of octanes, heat at 290-330°C for 30-60min under argon protection, then add 1-2mmol gadolinium trifluoroacetate, 0.1-0.2mmol ytterbium trifluoroacetate and 0.1-0.2mmol neodymium trifluoroacetate, UCNPs were obtained after heating at 290-330°C for 30-60min, followed by centrifugation and washing with ethanol for several times.

[0024] (2) Heat urea at a heating rate of 5-10°C / min to 500-600°C and keep it warm for 2-10 hours, then disperse the obtained yellow color in 1000mL deionized water, and add 5-10mL concentrated sulfuric acid and concentrated nitric acid respectively Stir at room temperature for 12-48 hours, disperse the obtained white solid...

Embodiment

[0028] Preparation method of satellite-shaped UCGM nanocomposite (the specific process is as follows: figure 1 shown):

[0029] (1) Synthesis of UCNPs: Take 1 mmol of gadolinium trifluoroacetate, 0.1 mmol of ytterbium trifluoroacetate and 0.05 mmol of thulium trifluoroacetate in a mixed solvent of 3.5 mL of oleic acid, 3.5 mL of oleylamine and 7.5 mL of octadecene. Heated at 330°C for 30min under gas protection, then added 1mmol gadolinium trifluoroacetate, 0.1mmol ytterbium trifluoroacetate and 0.1mmol neodymium trifluoroacetate, heated at 310°C for 60min, then centrifuged and washed with ethanol several times to obtain UCNPs.

[0030] (2) Heat urea at a heating rate of 5°C / min to 550°C for 4 hours, and disperse the obtained yellow solid in 1000mL of deionized water, add 10mL of concentrated sulfuric acid and concentrated nitric acid and stir at room temperature for 24 hours, and the obtained The white solid was dispersed in water, transferred to a reaction kettle, and heate...

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Abstract

The invention relates to a satellite-like UCGM nanocomposite material. The satellite-like UCGM nanocomposite material is a material obtained by synthesizing UCNPs and g-C3N4 nanoparticles into one through a CeOx reaction and carrying out modification with Met. A preparation method for the nanocomposite material comprises the following steps: firstly, synthesizing up-conversion nanoparticles (UCNPs) from trifluoroacetates of gadolinium, ytterbium, thulium and neodymium under the protection of high-temperature argon in a mixed solvent of oleic acid, oleylamine and octadecene; then, mixing graphene nitrogen carbide (g-C3N4) nanoparticles obtained by acidolysis and a high-temperature high-pressure reaction with the UCNPs in an ethanol solution; adding cerium nitrate (Ce(NO3)3.6H2O) and carrying out stirring at a normal temperature; adding a sodium hydroxide solution, and conducting centrifugal separation after a reaction; and finally, performing PEG modification in an aqueous solution, andadding metformin so as to eventually obtain the final product UCGM. According to the invention, the g-C3N4 nanoparticles with good biocompatibility are used as a photodynamic therapy material, and g-C3N4 is stimulated for photodynamic therapy.

Description

technical field [0001] The invention relates to a satellite-shaped UCGM nanocomposite material, a preparation method and application thereof, and belongs to the field of biological material research. Background technique [0002] According to the "World Cancer Report" released by the WHO in early 2014, the number of new cancer cases will reach 22 million each year in the next 20 years, and the number of cancer deaths will rise to 13 million during the same period. And affected by population growth and aging, 20% of the world's new cancer patients are in China. At present, 1 out of 5 people in our country dies of cancer. Traditional cancer treatment methods include surgery, radiation therapy and drug therapy. According to the different stages of tumor development, corresponding treatment methods can be adopted to achieve the best therapeutic effect. However, each treatment method has major disadvantages. In recent years, with the deepening of research, the application of va...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/51A61K47/02A61K47/18A61P35/00C09K11/02C09K11/77B82Y20/00B82Y30/00
CPCA61K9/5115A61K9/5123A61K41/0057A61P35/00B82Y20/00B82Y30/00C09K11/025C09K11/7766
Inventor 胡勇蒋炜朱剑锋张泰兴
Owner 南京大学深圳研究院
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