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A spindle-shaped cus@ceo 2 Nanocomposite material and preparation method

A nanocomposite material and spindle technology, applied in the field of biomaterials, can solve the problems of ineffective treatment of deep tumors, lack of treatment of deep tumors, and large particle size of nanoparticles, and achieve intelligent response to the tumor microenvironment, high photothermal conversion efficiency, and increased The effect of permeability

Active Publication Date: 2022-02-22
南京大学深圳研究院
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

XuanY et al. (Adv.Funct.Mater.2015,25,4689–4699) used radioactive 64 Cu is used as raw material to synthesize CuS nanoparticles with a particle size of about 30nm. This kind of nanoparticles can increase the sensitivity of radiotherapy through secondary reflection and thus improve the effect of radiotherapy. However, the particle size of this kind of nanoparticles is relatively large. The permeability of the tumor is not good, and at the same time, due to the condition that radiotherapy depends on oxygen, the effect of radiotherapy is not greatly improved
Qiwei Tian et al. (Adv.Mater.2011, 23, 3542–3547) synthesized petal-shaped CuS nanoparticles for photothermal therapy of tumors. This kind of treatment method is single, and there are shortcomings such as inability to treat deep tumors.
Kai Dong et al. (Adv. Mater. 2013, 25, 4452–4458) from Cu 2 O set out to prepare CuS nano hollow spheres with holes on the surface, and loaded the anticancer drug camptothecin in the holes for combined chemotherapy and hyperthermia treatment. This method uses combined treatment, compared with single treatment way, which effectively improves the effect of treatment, but also lacks effective treatment for deep tumors

Method used

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  • A spindle-shaped cus@ceo <sub>2</sub> Nanocomposite material and preparation method
  • A spindle-shaped cus@ceo <sub>2</sub> Nanocomposite material and preparation method
  • A spindle-shaped cus@ceo <sub>2</sub> Nanocomposite material and preparation method

Examples

Experimental program
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Embodiment

[0025] Spindle CuS@CeO 2 Preparation of nanocomposites (specific process such as figure 1 shown):

[0026] Weigh 17mgCuCl 2 ·H 2 O was added to 100mL deionized water, stirred in a 50°C water bath for 30min, then 14uL of mercaptoacetic acid was added, and the reaction was continued for 30min. The thioacetamide was added into the reaction system and reacted for 4 hours to obtain the copper sulfide reaction stock solution.

[0027] 500mgPAH and 217mgCe(NO 3 ) 3 ·6H 2 After O was added to the reaction system and stirred for 30 min, 0.5 mL NaOH (0.1 M) solution was prepared and poured into the reaction system. After reacting in a water bath at 50 °C for 12 hours, the spindle-shaped CuS@CeO was collected by centrifugation. 2 nanocomposites.

[0028] Spindle-shaped CuS@CeO prepared in the above examples 2 Nanocomposite materials through transmission electron microscopy figure 2 As shown, it can be clearly observed that the nanomaterials present a shuttle-shaped structure, ...

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Abstract

A spindle-shaped CuS@CeO 2 Nanocomposite materials, CuS nanoparticles provided with a coating of CeO 2 , add copper chloride, mercaptoacetic acid, and thioacetamide to react in a constant temperature water bath to generate copper sulfide CuS nanoparticles and a synthetic stock solution; then continue to add polyallylamine hydrochloride and cerium nitrate to the CuS synthetic stock solution and stir at constant temperature , then heated in a water bath, adding sodium hydroxide solution to continue the reaction, and the reaction product was freeze-dried to obtain a spindle-shaped CuS@CeO 2 Nanocomposite material; the coating layer CeO of described CuS nanoparticle 2 It is prepared through a one-step reaction; the present invention uses CuS nanoparticles with low price and good biological affinity as photothermal conversion and radiotherapy sensitization materials, which can absorb near-infrared light well and convert it into heat, and at the same time Increase the therapeutic effect of radiotherapy in radiotherapy.

Description

technical field [0001] The present invention relates to a spindle type CuS@CeO 2 The nanocomposite material and its preparation method and application belong to the field of biological material research. Background technique [0002] According to the "World Cancer Report" released by the WHO in early 2014, the number of new cancer cases will reach 22 million each year in the next 20 years, and the number of cancer deaths will rise to 13 million during the same period. And affected by population growth and aging, 20% of the world's new cancer patients are in China. At present, 1 out of 5 people in our country dies of cancer. Traditional cancer treatment methods include surgery, radiation therapy, and drug therapy. According to the different stages of tumor development, corresponding treatment methods can be adopted to achieve the best therapeutic effect. Among them, in the early stage of solid tumors, surgical operations are generally used to remove the tumor tissue, and c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K47/02A61P35/00C01F17/235C01G3/12C01F17/10B82Y5/00B82Y30/00B82Y40/00
CPCA61K41/0052A61K41/0038A61K47/02A61P35/00C01G3/12B82Y5/00B82Y30/00B82Y40/00C01P2004/80C01P2004/30C01P2004/04C01P2004/03C01P2004/64C01P2004/62
Inventor 胡勇蒋炜刘诗宜罗星谕朱剑锋
Owner 南京大学深圳研究院
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