A kind of metal organic nano compound and its preparation and application

A nano-compound and metal-organic technology, applied in the fields of nanomaterials and biomedical materials, can solve the problems of slowness, structural collapse, unstable coordination bonds, etc., and achieve the effects of easy scale, mild conditions and simple preparation process.

Inactive Publication Date: 2017-08-25
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional metal-organic nano-compounds collapse the structure through the relatively unstable coordination bond between the metal and the ligand, that is, the drug release is mainly controlled by the pH value response.
The above-mentioned dissociation process is a slow degradation process, and the result is that the degradation time of metal-organic nano-compounds in the body is longer, which is not conducive to its clearance in the body.

Method used

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  • A kind of metal organic nano compound and its preparation and application
  • A kind of metal organic nano compound and its preparation and application
  • A kind of metal organic nano compound and its preparation and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A method for preparing metal-organic nano-compounds as described above, comprising the following steps:

[0032] (a) will 4,4 ’ - Dithiodibenzoic acid and zirconium salt are dissolved in a mixed solution consisting of DMF, acetic acid and deionized water at a molar ratio of 1:1; the dosage ratio of DMF, acetic acid and deionized water is: 15ml: 0.38ml: 33μl;

[0033] (b) Place the reaction solution in step (a) at 40°C to react until the solution turns into a white turbid solution, and stop the reaction;

[0034] (c) After cooling, centrifuge and wash with DMF and deionized water respectively to obtain the product.

[0035] The morphology of the product obtained in step (c) is nanorods, the hydrodynamic particle size is 200-250nm, the surface is positively charged, the surface has a mesoporous structure, the pore diameter is 1.85nm, and the specific surface area is 441.67m 2 / g.

Embodiment 2

[0037] A method for preparing metal-organic nano-compounds as described above, comprising the following steps:

[0038] (a) will 4,4 ’ - Dithiodibenzoic acid and zirconium salt are dissolved in a mixed solution consisting of DMF, acetic acid and deionized water at a molar ratio of 1:1; the dosage ratio of DMF, acetic acid and deionized water is: 15ml: 0.19ml: 33μl;

[0039] (b) Place the reaction solution in step (a) at 20°C to react until the solution turns into a white turbid solution, and stop the reaction;

[0040] (c) After cooling, centrifuge and wash with DMF and deionized water respectively to obtain the product.

[0041] The morphology of the product obtained in step (c) is nanorods, the hydrodynamic particle size is 200-250nm, the surface is positively charged, the surface has a mesoporous structure, the pore diameter is 1.75nm, and the specific surface area is 400.32m 2 / g.

Embodiment 3

[0043] A method for preparing metal-organic nano-compounds as described above, comprising the following steps:

[0044] (a) will 4,4 ’ - Dithiodibenzoic acid and zirconium salt are dissolved in a mixed solution consisting of DMF, acetic acid and deionized water in a molar ratio of 1:1; the dosage ratio of DMF, acetic acid and deionized water is: 15ml: 0.76ml: 33μl;

[0045] (b) Place the reaction solution in step (a) at 120°C to react until the solution turns into a white turbid solution, and stop the reaction;

[0046] (c) After cooling, centrifuge and wash with DMF and deionized water respectively to obtain the product.

[0047] The shape of the product obtained in step (c) is nanosphere, the hydrodynamic particle size is 200~250nm, the surface is positively charged, the surface has a mesoporous structure, the pore diameter is 0.83nm, and the specific surface area is 340.24m 2 / g.

[0048] Product performance testing:

[0049] 1) Powder diffraction instrument Bruker D8 A...

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Abstract

The invention relates to a preparation method and application of a metal organic nanometer compound. The metal organic nanometer compound with a chemical formula of {[Zr(BPDC-S-S)]}infinity is named as UIO-67-S-S and is formed by precipitation of zirconium tetrachloride, used as a metal salt, and 4,4-dithiosalicylic acid, used as organic ligand, in DMF mixed liquor through coordination. The UIO-67-S-S nanometer compound can be used as a drug release carrier for response to dual pH and redox stimulation.

Description

technical field [0001] The invention relates to the technical field of nanomaterials and the field of biomedical materials, in particular to a metal organic nano compound and its preparation and application. Background technique [0002] Metal-organic framework materials are a class of porous materials composed of organic ligands and metal ions through coordination bonds, and have a high specific surface area. Moreover, MOFs with different structures and functions can be obtained by choosing different metal ions and ligands. It is precisely because of the diversity of structural properties of this material and its unique porous structure that it has a wide range of applications in the field of drug delivery. However, the traditional metal-organic nano-compounds collapse their structure through the relatively unstable coordination bond between the metal and the ligand, that is, the drug release is mainly controlled by the pH value response. The above-mentioned dissociation ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C323/62C07C319/22A61K47/24
CPCA61K47/24C07C319/22C07C323/62
Inventor 朱春玲柯淑娟蒋有华曾胚羡谢增鸿
Owner FUZHOU UNIV
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