Application of a kind of traditional Chinese medicine monomer in preparation of medicine for treating endometriosis

A technology for endometriosis and endometriosis, applied in the direction of drug combinations, pharmaceutical formulas, plant raw materials, etc., can solve the problems that it is difficult to explain the basic pathological characteristics of endometriosis and the clinical efficacy is unsatisfactory

Active Publication Date: 2020-09-22
JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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Problems solved by technology

However, it is difficult to explain the basic pathological features of endometriosis simply by using the "blood stasis theory"
Endometriosis is still a common and difficult disease in women of reproductive age, and the clinical efficacy is still unsatisfactory

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0009] 1. Identification of heterotopic stromal cells

[0010] Obtain ectopic endometrial tissue from ovarian EMs patients undergoing laparotomy or laparoscopy, put it into a sterile bottle pre-filled with PBS, and transport it to the laboratory for processing within 2 hours. Rinse the tissue specimens with normal saline in a sterile environment, cut them into small pieces, digest them with IV collagenase, filter them through 80-mesh and 300-mesh sieves, and centrifuge them at 1000rpm / min for 10min to obtain endometriosis ectopic lesions endoplasmic cells (EESCs). EESCs were seeded in 6-well culture plates in 5% CO 2 , 37 ℃ cell incubator culture. When the cells grew to 80%, fixed with 4% paraformaldehyde and blocked with 3% hydrogen peroxide, the primary antibody was added dropwise and incubated for 1 hour; the secondary antibody was added dropwise and incubated for 30 minutes. Finally, DAB chromogen was dropped into each well, and observed under a microscope, the heteroto...

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Abstract

The invention provides a traditional Chinese medicine monomer for treating endometriosis. Treatment medicines comprise the traditional Chinese medicine monomer and compound medicine-containing serum.The traditional Chinese medicine monomer comprises cinnamyl aldehyde. The compound medicine-containing serum is made of traditional Chinese medicines including lignum dalbergiae odoriferae, lignum aquilariae resinatum, radix cyathulae and faeces trogopterori. The traditional Chinese medicine monomer has the advantages that proliferation of interstitial cells at ectopic foci of the endometriosis can be obviously inhibited by the traditional Chinese medicine monomer at in-vitro cell levels, certain effects of promoting apoptosis of the interstitial cells at the ectopic foci of the endometriosiscan be realized by the traditional Chinese medicine monomer, the traditional Chinese medicine monomer can be used for developing medicines for the endometriosis, and endometriosis treatment auxiliaryenhancement effects for the traditional Chinese medicine monomer can be realized by the medicine-containing serum.

Description

Technical field: [0001] The invention relates to the field of research and development of gynecological medicines, in particular to a traditional Chinese medicine monomer for treating endometriosis. Background technique: [0002] Since the third meeting of the Obstetrics and Gynecology Professional Committee of the Chinese Society of Integrative Medicine held in Xi'an in 1990, the diagnosis and treatment standards for endometriosis (endsometriosis EMs) revised by the meeting have identified this disease as " Blood stasis syndrome", from which the relationship between this disease and blood stasis has been recognized. However, it is difficult to explain the basic pathological features of endometriosis simply by "blood stasis theory". Endometriosis is still a common and difficult disease in women of childbearing age, and the clinical efficacy is still unsatisfactory. Therefore, we propose a new pathogenesis of endometriosis: either due to physical constitution, exogenous pat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/835A61P15/00A61K31/11A61K35/24
CPCA61K31/11A61K35/24A61K36/21A61K36/48A61K36/835A61K2300/00
Inventor 梁瑞宁
Owner JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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