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Luseogliflozin composition

A technology of luxagliflozin and composition, applied in the field of luxagliflozin tablet composition, can solve problems such as large electrostatic adsorption, dissolution rate not up to standard, content uniformity is difficult to control, etc., and achieve high dissolution rate and uniform content degree of stability

Inactive Publication Date: 2018-02-16
WEIHAI GUANBIAO INFORMATION TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the process of preparation development, the dissolution rate is not up to the standard. In order to improve the dissolution rate, the dissolution rate is generally improved by controlling the particle size of the main drug. Solved the problem that the content uniformity is difficult to control

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1. D90 is 2.5g of rugaggliflozin with 48 microns, 70g of lactose, 1.5g of sodium lauryl sulfate, 8g of sodium citrate, 7g of sodium bicarbonate, 8g of beta cyclodextrin, 8mg of povidone K30, Crospovidone 3g, magnesium stearate 1g. Prepare 1000 tablets according to the preparation method described in the technical scheme.

Embodiment 2

[0024] Example 2. D90 is 76 micron rugagliptin 5g, lactose 86g, sodium lauryl sulfate 0.8g, sodium citrate 15g, sodium bicarbonate 4g, beta cyclodextrin 16g, povidone K30 3g, Lipovidone 8g, magnesium stearate 1.5g. Prepare 1000 tablets according to the preparation method described in the technical scheme.

Embodiment 3

[0025] Example 3. D90 is 2.5g of rugaggliflozin of 60 microns, 78g of lactose, 1.2g of sodium lauryl sulfate, 10g of sodium citrate, 5g of sodium bicarbonate, 10g of beta cyclodextrin, 5g of povidone K30, Crospovidone 5g, magnesium stearate 1.3g. Prepare 1000 tablets according to the preparation method described in the technical scheme.

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PUM

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Abstract

The invention relates to luseogliflozin composition and belongs to the technical field of pharmaceutic preparations. According to the technical scheme, a unit dose of the composition contains 2.5-5 mgof luseogliflozin with the D90 being 48-76 mu m, 70-86 mg of lactose, 0.8-1.5 mg of lauryl sodium sulfate, 8-15 mg of sodium citrate, 4-7 mg of sodium bicarbonate, 8-16 mg of beta-cyclodextrin, 3-8 mg of povidone K30, 3-8 mg of crosslinking polyvinyl pyrrolidone and 1-1.5 mg of magnesium stearate. According to the technical scheme, the luseogliflozin tablet composition with high dissolution rateand stable content uniformity is provided.

Description

technical field [0001] The invention relates to a lupagliflozin tablet composition, which belongs to the technical field of pharmaceutical preparations. Background technique [0002] Diabetes is a group of metabolic diseases characterized by hyperglycemia. According to statistics from the International Diabetes Federation, there were 387 million people with diabetes worldwide in 2014, and it is expected to reach 592 million in 2035. Type 2 diabetes is the most common form of diabetes, accounting for approximately 90% of diabetic patients. [0003] Diabetes can lead to chronic damage and dysfunction of various tissues in the human body, especially the eyes, kidneys, heart, blood vessels, and nerves. Once you become a diabetic, you need to take medicine for life. Diabetes not only affects the quality of life of patients, but may also lead to shortened life expectancy. [0004] Luxagliflozin, the English name Luseogliflozin, has two specifications of 2.5mg and 5mg, and is a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/382A61K47/20A61K47/12A61K47/02A61K47/40A61K9/20A61P3/10
CPCA61K31/382A61K9/2009A61K9/2013A61K9/2018A61K9/2059A61K47/02A61K47/12A61K47/20A61K47/40
Inventor 孙爱梅
Owner WEIHAI GUANBIAO INFORMATION TECH