Combined medicine for treating non-small cell lung cancer

A non-small cell lung cancer and drug technology, applied in the field of medicine, can solve problems such as cancer treatment that has not yet been seen, achieve significant effects, reduce drug resistance, and increase efficacy

Active Publication Date: 2018-02-16
SICHUAN GOODDOCTOR PANXI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no report on the combination of P

Method used

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  • Combined medicine for treating non-small cell lung cancer
  • Combined medicine for treating non-small cell lung cancer
  • Combined medicine for treating non-small cell lung cancer

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0023] Example 1 Preparation of American cockroach extract

[0024] Weigh the American cockroach, pulverize, add 12 times the weight of the original medicinal material, 80% ethanol, reflux and extract 3 times at 80°C for 1 hour, filter, and concentrate the filtrate under reduced pressure to a specific gravity of 1.10~1.20 (60~65 Measured at ℃), add 12 times the weight of the concentrated solution to the concentrated solution, stir for 20 minutes at 75°C, keep it still in cold storage, absorb the upper layer of grease with filter paper, filter the lower layer, concentrate, dry, and crush under reduced pressure. It is the extract of American cockroach.

Example Embodiment

[0025] Example 2 Preparation of American cockroach powder

[0026] The adult American cockroach was placed in a vacuum desiccator and dried at 45°C to a moisture content of 2% to obtain a dried American cockroach adult; the dried American cockroach adult was placed at a temperature of -150°C Pulverize to 200 mesh in an ultra-low temperature pulverizer to obtain American cockroach powder.

Example Embodiment

[0027] Example 3

[0028] The combined medicine of the American cockroach and gefitinib includes, in parts by weight: 4500 mg of the American cockroach extract described in Example 1, and 233 mg of gefitinib.

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Abstract

The invention provides a combined medicine for treating non-small cell lung cancer. The medicine contains the active ingredients including american cockroach and gefitinib, wherein american cockroachadopts american cockroach extract or american cockroach medicinal powder, and the weight ratio of the active ingredients of the medicine, namely, the american cockroach extract to gefitinib is (4200-5000): 233, preferably, american cockroach extract to gefitinib is 4500 to 233; american cockroach medicinal powder to gefitinib is (2300-3200): 233, preferably, american cockroach medicinal powder togefitinib is 3000 to 233. The medicine has an obvious effect in treating cancer, especially has an obvious effect when taken as the medicine for treating non-small cell lung cancer, the obvious synergistic effect is achieved after american cockroach and gefitinib are combined for use, the efficiency is higher than that obtained by independently using gefitinib or american cockroach, meanwhile, thedrug tolerance generated when gefitinib or american cockroach is independently used can be reduced, and thus the effect of the medicine in treating cancer is guaranteed.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to a combination medicine for treating non-small cell lung cancer. Background technique [0002] Lung cancer is a common clinical malignant tumor. Among many cancers, lung cancer ranks first in the global cancer mortality rate. Non-small cell lung cancer (NSCLC) accounts for 80% of lung cancer. Lung cancer is one of the first types of cancer to use targeted therapy in the clinic. Small molecule compound tyrosine kinase inhibitors are widely used in clinical targeted therapy of NSCLC patients, and their target is epidermal growth factor receptor (Epidermal Growth Factor Receptor, EGFR). [0003] Gefitinib (Gefitinib), the chemical name is 4-(3-chloro-4-fluoroaniline)-7-methoxy-6-(3-isopropyleneoxy)quinazoline, which is a synthetic aniline A quinazoline compound is a selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. It is suitable for the third-line, second-line o...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61P35/00A61K31/5377
CPCA61K31/5377A61K35/63A61K2300/00
Inventor 耿福能林庆华沈咏梅
Owner SICHUAN GOODDOCTOR PANXI PHARMA
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