High-efficient nanoparticle emulsion synthesis process

Abstract

The invention discloses a high-efficient nanoparticle emulsion synthesis process. The high-efficient nanoparticle emulsion synthesis process comprises the following steps: weighing soluble trivalent iron salt and sodium acetate, dissolving the soluble trivalent iron salt and sodium acetate into ethylene glycol, and performing stirring to obtain yellow transparent liquid; preparing a mixed aid; mixing cyclohexane and the mixed aid; dropwise adding the yellow liquid into the above step; adding trisodium citrate, a polyvinylpyrrolidone dispersing agent and an alkaline additive, and performing magnetic stirring to obtain microemulsion; performing ageing treatment and suction filtration to obtain a filter cake; performing washing, performing separation via an external magnetic field, and performing vacuum drying to obtain a magnetic nanoparticle. According to the nanoparticle synthesis process of the invention, a ferroferric oxide magnetic nanoparticle is synthesized by using a microemulsion method, an obtained powder body is narrow in size distribution and has pure components, and anhydrous sodium acetate with good electrostatic stability is selected as the alkaline additive, so that agglomeration of magnetic nanoparticles is effectively avoided, and the prepared ferroferric oxide magnetic nanoparticle is good in stability, and good in underwater single dispersion, superparamagnetism and grain size uniformity.

Description

technical field [0001] The invention relates to an inorganic material preparation process, in particular to a high-efficiency synthesis process of nano-microsphere emulsion. Background technique [0002] As a soft magnetic material, magnetic nanomaterials are widely used in magnetic media storage, magnetic resonance imaging, catalysts and other fields. Iron tetroxide has attracted much attention due to its good magnetic properties, biocompatibility and low toxicity. At present, The research on ferroferric oxide has been extended to the field of biomedicine, especially the research on targeted drug delivery. Using an external magnetic field can enrich the magnetically targeted drug carrier containing nanometer ferric oxide in the lesion in the body, reducing the Small normal tissue drug contact, reduce toxic and side effects, can effectively reduce the amount of drugs, improve the efficacy of drugs. [0003] At present, the preparation methods of ferroferric oxide mainly inc...

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is that the preparation method of the existing ferroferric oxide magnetic nano microspheres has poor dispersion, uneven particle size, difficult size control, and easy generation of impurity phases, making the product impure. The purpose is to provide high-efficiency nano Microsphere emulsion synthesis process, using the microemulsion method to synthesize ferroferric oxide magnetic nano-microspheres, the obtained powder has a narrow particle size distribution and pure components, and anhydrous sodium