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A kind of isopentyl diphenyl ether compound and its preparation method and application

A technology of isopentyl diphenyl ether and compounds, which is applied in the field of phytochemistry, can solve problems such as applications that have not been seen in relevant reports, and achieve the effects of inhibiting spoilage, good antibacterial activity, and easy industrial production

Active Publication Date: 2020-06-16
CHINA TOBACCO YUNNAN IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention separates an isopentyl diphenyl ether compound from Flos Lonicerae, activity research shows that the compound has good antibacterial activity, and no related reports have been seen on the compound and its use

Method used

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  • A kind of isopentyl diphenyl ether compound and its preparation method and application
  • A kind of isopentyl diphenyl ether compound and its preparation method and application
  • A kind of isopentyl diphenyl ether compound and its preparation method and application

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Experimental program
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Effect test

Embodiment 1

[0034] The preparation of embodiment 1-compound

[0035] The honeysuckle sample comes from Kunming, Yunnan, and the variety is Honeysuckle Tree No. 3. Sampling 2.5 kg of dried honeysuckle, pulverized and extracting 5 times with 95% methanol for 45 minutes each time. The extracts were combined, filtered, and concentrated under reduced pressure to form an extract to obtain 165 g of extract. The extract is dissolved in pure methanol with a weight ratio of 2.0 times, and then mixed with 180 g of 100 mesh thick silica gel, and 1.2 kg of 160 mesh silica gel is packed for silica gel column chromatography, and the volume ratio is 1:0, 20:1, 9:1, 8:2, 7:3, 6:4, 1:1, 1:2 chloroform-acetone gradient elution, TLC monitoring and merging the same parts to obtain 8 parts, wherein the volume ratio is 9: The chloroform-acetone eluted part of 1 was separated by Agilent 1100 semi-preparative high-performance liquid chromatography, with 68% methanol as mobile phase, Zorbax SB-C18 (21.2×250mm, 5 ...

Embodiment 2

[0036] The preparation of embodiment 2-compound

[0037] The honeysuckle sample comes from Linyi, Shandong Province, and the variety is Beihua No. 1. The dried honeysuckle sample is crushed to 30 meshes, 4.2kg is sampled, extracted 4 times with 95% ethanol, each extraction is 40 minutes, the extracts are combined, filtered, Concentrated under reduced pressure to obtain an extract, 302 g of extract was obtained. The extractant is dissolved in pure methanol with a weight ratio of 2.0 times, and then mixed with 320 g of 80 mesh thick silica gel, and 2.2 kg of 200 mesh silica gel is packed into a column for silica gel column chromatography, and the volume ratio is 1:0, 20:1, 9:1, 8:2, 7:3, 6:4, 1:1, 1:2 chloroform-acetone gradient elution, TLC monitoring and merging the same parts to obtain 8 parts, wherein the volume ratio is 9: The chloroform-acetone eluted part of 1 was separated by Agilent 1100 semi-preparative high-performance liquid chromatography, with 68% methanol as mobi...

Embodiment 3

[0038] The preparation of embodiment 3-compound

[0039] The honeysuckle sample comes from Emei, Sichuan, and the variety is Shandong Fujimoto Damaohua. Sampling 5.8kg of honeysuckle is crushed, extracted 3 times with 75% acetone, and extracted 50 minutes each time. The extracts are combined, filtered, and concentrated under reduced pressure to form an extract. , to obtain extract 427g. The extract is dissolved in pure methanol with a weight ratio of 1.6 times, and then mixed with 480 g of 90 mesh thick silica gel, and 3.2 kg of 180 mesh silica gel is packed into a column for silica gel column chromatography, and the volume ratio is 1:0, 20:1, 9:1, 8:2, 7:3, 6:4, 1:1, 1:2 chloroform-acetone gradient elution, TLC monitoring and merging the same parts to obtain 8 parts, wherein the volume ratio is 9: The chloroform-acetone eluted part of 1 was separated by Agilent 1100 semi-preparative high-performance liquid chromatography, with 68% methanol as mobile phase, Zorbax SB-C18 (21....

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Abstract

The invention discloses an isoamyl diphenyl ether compound, a preparation method and application thereof. The compound is obtained by separating and purifying flos lonicerae japonicae through extractextraction, silica gel column chromatography and high pressure liquid chromatography, has a molecular formula of C21H24O4, having the following structural formula. The compound is named lonicera japonica diphenyl ether-A; English name: Japanicadiphenyl ether A. The experiment shows that the compound has good antibacterial activity and can be used for preparing bacteriostatic agents. In particular,the compound has a good application prospect for suppressing spoilage and deterioration of tobacco liquid and prolonging the shelf life of tobacco liquid.

Description

technical field [0001] The invention belongs to the technical field of phytochemistry, and in particular relates to an isopentyl diphenyl ether compound extracted from honeysuckle for the first time, and the compound has good antibacterial activity. Simultaneously, the invention also relates to a preparation method of the compound, and an application of the compound in preventing corruption of tobacco material liquid and prolonging shelf life of tobacco material liquid. Background technique [0002] Natural preservatives, also known as natural organic preservatives, are substances with antibacterial effects secreted by organisms or present in the body, which are artificially extracted or processed. Such preservatives are natural substances, some of which are food components themselves, so they are non-toxic to the human body and can improve the flavor quality of food, so they are a kind of food preservatives with development prospects. As food safety and health functions in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C45/78C07C49/255A24B15/30
CPCA24B15/26A24B15/303C07C45/78C07C49/255
Inventor 刘欣张承明李晶蒋次清王晋孔维松耿永勤李雪梅杨叶昆许永周敏杨光宇胡秋芬
Owner CHINA TOBACCO YUNNAN IND
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