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Preparation method of nano calcium hydroxide for root canal filling material

A calcium hydroxide, root canal filling technology, applied in nanotechnology for material and surface science, calcium/strontium/barium oxide/hydroxide, nanotechnology, etc., can solve the problem that nano calcium hydroxide cannot be used in clinical root canal treatment and other issues, to save preparation and waiting time, facilitate dispersion, and save time

Inactive Publication Date: 2018-03-30
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention is a method for preparing nanometer calcium hydroxide root canal filling materials for root canal filling materials provided in view of the fact that nanometer calcium hydroxide root canal filling materials obtained in the prior art cannot be applied to clinical root canal treatment.

Method used

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  • Preparation method of nano calcium hydroxide for root canal filling material
  • Preparation method of nano calcium hydroxide for root canal filling material
  • Preparation method of nano calcium hydroxide for root canal filling material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Modified CaCl with PEG400 bonding 2 : Take 150mmol / L of CaCl 2 Solution 30ml joins in the 250ml conical flask of autoclaving, then adds the PEG400 solution 10ml of 4.2mmol / L in the bottle, seals the conical flask bottleneck with aseptic tinfoil, ultrasonic cleaner vibrates 2h, and described ultrasonic frequency is 2×10 4 ~10 9 Hz, to obtain CaCl coated with inhibitor PEG400 2 solution.

Embodiment 2

[0033] Preparation of nano-calcium hydroxide wet gel: use the digitally controlled syringe pump, sterile drug-dissolving syringe and syringe pump extension tube to form a closed aseptic reaction system, and use a 50ml sterile drug-dissolving syringe to draw 150mmol / L 50ml of NaOH, carefully installed on the digital control syringe pump, connected with the extension tube of the sterile syringe pump, and the other end of the extension tube passed through the mouth of the Erlenmeyer bottle to seal the tin foil and connected to the Erlenmeyer flask to form a closed sterile titration device (such as figure 2 shown). Turn on the power supply of the syringe pump and set the infusion rate to 20ml / L, the infusion time to 2.5h, the alarm switch after the injection is completed, and then start the infusion key to start injecting CaCl into the Erlenmeyer flask. 2 Infusion of NaOH. At the same time, stir the reaction liquid in the Erlenmeyer flask with a magnetic stirrer at a speed of 2 ...

Embodiment 3

[0035] Dry the nano-calcium hydroxide wet gel and obtain dispersed nano-powder: transfer the wet gel obtained after centrifugation to a flat-bottomed Erlenmeyer flask, add 50ml of n-butanol, stir with a magnetic stirrer for 1h, and then vibrate with ultrasonic waves for 30min. The ultrasonic frequency is 2×10 4 ~10 9 Hz, heated to reflux, and the temperature was gradually raised from the azeotropic point of 366K of n-butanol and water to 399K of the boiling point of n-butanol, so that the water and n-butanol were volatilized, and the wet gel obtained was put into a vacuum dryer for suction filtration, and a white precipitate was obtained. Heat in a vacuum drying oven, and dry at a temperature of 353K for 24 hours to obtain the root canal filling material matrix nano-calcium hydroxide powder required for the experiment.

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Abstract

The invention provides a preparation method of nano calcium hydroxide for a root canal filling material. The preparation method comprises the following steps of: (1) bonding modification: modifying and coating CaCl2 with polyethylene glycol 400, and performing ultrasonic vibration for ageing of CaCl2, (2) preparation of wet gel of nano calcium hydroxide: titrating CaCl2 obtained in the previous step with NaOH, and performing magnetic stirring and ultrasonic vibration to prepare the nano wet gel, and (3) drying: preparing nano-powder by an n-butyl alcohol azeotropic distillation drying method,and performing magnetic stirring, ultrasonic vibration, heating and azeotropic reflux, suction filtration and drying to form the nano calcium hydroxide powder. The method is more scientific, advancedand reasonable, saves time and manpower and reduces labor intensity, and prepared nano calcium hydroxide is larger in particle size and specific surface area, higher in dispersity and more suitable asa substrate of the root canal filling material.

Description

technical field [0001] The invention relates to a dental material, in particular to a preparation method of nano calcium hydroxide used for root canal filling materials. Background technique [0002] Although the human oral cavity is a special environment with more than 700 kinds of resident bacteria, only when the crown of the host is carious, fractured or worn, the enamel or cementum on the tooth surface is destroyed, and the dentin is exposed. About 25% of the bacteria in the oral flora will directly enter the pulp cavity through the oral cavity, or enter the pulp cavity retrogradely from the apical foramen and side and accessory root canals of the periodontal tissue, breaking through the host's immune antibacterial system, causing the whole or root Inflammatory lesion and necrosis of pulp tissue, periapical disease of the pulp causing bacterial infection of dentin tubules. This kind of bacterial infection in the root canal is different from other tissue infections in th...

Claims

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Application Information

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IPC IPC(8): A61K6/02A61K6/087C01F11/02B82Y30/00A61K6/891
CPCA61K6/80A61K6/891B82Y30/00C01F11/02C01P2002/82C01P2004/04C08L71/02
Inventor 王籽明范伟杨柳孙青
Owner WUHAN UNIV
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