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Application of orientin in preparation of antibacterial drugs

An antibacterial and drug technology, used in antibacterial drugs, resistance to vector-borne diseases, pharmaceutical formulations, etc., can solve the problems of strong accumulation of antibacterial drugs, irritation, dizziness, allergies, etc.

Inactive Publication Date: 2018-04-03
ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Antibacterial drugs have been widely used in the treatment of AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) , but these antibacterial drugs have strong cumulative toxicity, often causing liver and kidney damage, gastrointestinal irritation, dizziness, allergies, etc., so looking for new antibacterial drugs with unique mechanism of action has become one of the hot spots in drug research and development today

Method used

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  • Application of orientin in preparation of antibacterial drugs
  • Application of orientin in preparation of antibacterial drugs
  • Application of orientin in preparation of antibacterial drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: the preparation of compound Orientin tablet involved in the present invention:

[0014] Take 5 grams of compound Orientin, add 195 grams of dextrin, mix well, and make 1000 tablets by conventional compression.

Embodiment 2

[0015] Embodiment 2: the preparation of the compound Orientin capsule involved in the present invention:

[0016] Take 5 grams of compound Orientin, add 195 grams of starch, mix well, and pack into capsules to make 1000 capsules.

[0017] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0018] Experimental example 1: Experimental research on the antibacterial activity of Orientin

[0019] The antibacterial activity experiment is the method of concentration dilution, and each measurement is repeated three times. The test pathogens include Escherichia coli, Pseudomonas fluorescens, Staphylococcus aureus, Proteus, and Cryptococcus neoformans, and the concentration of the bacteria solution is 10 5 individual / mL. The initial concentration of Orientin was 50.0 μg / mL (5% dimethyl sulfoxide DMSO), and it was serially diluted to 0.098 μg / mL. The equal volume of bacterial liquid and test samples were mixed and cultured in a 96-well plate, and the bacterial culture temperature was respectively 37°C, observe after 24 hours of incubation, if no colonies are found, it is the lowest antibacterial concentration of the sample, that is, the MIC value. The positive control of this experiment is amikacin sulfate, and the antibacterial results of Orientin are shown in Table 1. ...

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Abstract

The invention relates to application of orientin in preparation of antibacterial drugs. Orientin has strong inhibition effect on Escherichia coli, Pseudomonas fluorescens, Staphylococcus aureus, Proteusbacillus vulgaris and Cryptococcus neoformans, and thus, orientin can be used as an antibacterial compound. The application of orientin in preparation of antibacterial drugs is disclosed for the first time; orientin has good bacteriostasis activity; the application of orientin has outstanding substantive distinguishing features; meanwhile, substantial progress is made as orientin is applied to prevention and treatment of bacterial infections.

Description

technical field [0001] The present invention relates to a new application of compound Orientin, in particular to the application of Orientin in the preparation of antibacterial drugs. Background technique [0002] Antibacterial drugs have been widely used in the treatment of AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) , but these antibacterial drugs have strong cumulative toxicity, often causing liver and kidney damage, gastrointestinal irritation, dizziness, allergies, etc., so looking for new antibacterial drugs with unique mechanism of action has become one of the hot spots in drug research and development today. [0003] The compound Orientin involved in the present invention is a new compound published in 2013 (Ebenezer de Mello Cruz, et al., Leishmanicidal activity of Cecropia pachystachya flavonoids: Arginase inhibition and altered mitochondrial DNA arrangement. Phytochemistry, 89 (2013) 71-77.), the The compound ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K9/48A61K9/20A61P31/04
CPCA61K9/2059A61K9/4866A61K31/7048Y02A50/30
Inventor 田丽华
Owner ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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