Rotating disc type animal phototoxicity rapid tester

Abstract

The invention provides a rotating disc type animal phototoxicity rapid tester which includes an illumination cabin and a rotating disc which are installed on a fixed platform provided with a movable supporting component. A plurality of spring supports are positioned on the rotating disc with the rotating speed controlled by a stepping motor and can fix a tested mouse cage containing an experimental animal. When the tested mouse cage moves to the illumination cabin, a cabin inlet movable door and a cabin outlet movable door can be automatically switched on and switched off, a UV light source module in the illumination cabin sends out a UVA light source of 365 nm with a single wavelength and a suitable intensity to perform phototoxic irradiation experiments on experimental animals. Soft sunblinds are mounted around the bottom of the illumination cabin to ensure UVA light source purity during the experiments and light intensity accuracy, and in the experiments, a computer controller controls and records the process of each experiment, results and other parameters or the parameters are output to a printer to print a lab report. The rotating disc type animal phototoxicity rapid testerhas the advantages that the the phototoxicity irradiation experiment of small animals can be quickly and automatically completed. Light intensity and irradiation time required for the experiments canbe automatically controlled, the stray light interference is small, the experimental efficiency is improved, and experimental data is accurate and reliable.

Description

technical field [0001] The invention relates to a turntable type rapid tester for phototoxicity of animals. Background technique [0002] People are exposed to various chemical substances in their lives, especially daily chemicals or additives in articles. These chemical substances have the possibility of causing harm to the human body under the condition of sunlight exposure, which is manifested as erythema and edema followed by pigmentation and peeling of the skin within minutes or hours after exposure to sunlight, which requires the inspection of such chemicals Phototoxicity test detection: observe whether the skin of the tested animals has thick, red, swollen, macule, blisters and other adverse reactions after being irradiated with a certain dose of UVA light, and compare and determine whether the tested substance is phototoxic to animals according to the relevant regulations. It is deduced whether it may cause phototoxicity damage to humans; the previous phototoxicity ...

AI Technical Summary

Problems solved by technology

These chemical substances have the possibility of causing harm to the human body under the condition of sunlight exposure, which is manifested as erythema and edema followed by pigmentation and peeling of the skin within minutes or hours after exposure to sunlight, which requires the inspection of such chemicals Phototoxicity test detection: observe whether the skin of the tested animals has thick, red, swollen, macule, blisters and other adverse reactions after being irradiated with a certain dose of UVA light, and compare and determine whether the tested substance is phototoxic to animals according to the relevant regulations. It is deduced whether it may cause phototoxicity damage to humans; the previous phototoxicity identification test equipment is relatively simple, and only one or a few test animals can be used for each test. When a large number of phototoxicity tests need to be done, batches are replaced The tested mouse cages with the animals installed need to be replaced batch by batch, which is time-consuming and discontinuous, and the detection efficiency is low. Therefore, a kind of animal phototoxicity detection system can be developed that can place and remove the tested mouse cages at any time, and automatically and continuously detect them. Rapid tester becomes imperative

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