Method for quantifying specific bitterness of medicine

Abstract

The invention relates to a method for quantifying specific bitterness of a medicine. The method comprises the following steps: at 37 DEG C, by a classic population tasting experimental method, tastingbitterness at the mass volume concentration (Cr) of a reference solution by twenty or more trained volunteers to acquire standard apparent bitterness, namely moderate bitterness 3; by a method of establishing an effective standard apparent bitterness-concentration model of a substance to be tested first and then reversely reckoning the concentration, acquiring the corresponding concentration (Cs)under the equal bitterness of the sample to be tested, wherein the specific bitterness ROB is equal to (Cr) / (Cs). By the method for quantifying the specific bitterness of the medicine, the bitternessof a traditional Chinese medicinal single substance can be effectively measured, an accurate and objective measurement result is obtained, a quantitative index is provided for bitterness evaluation of the medicine, a technical support is provided for taste masking of the medicine, the commercial value of the medicine is exploited, and the medicine taking effect is improved; therefore, the methodfor quantifying the specific bitterness of the medicine has significant economic and social benefits.

Description

Technical field [0001] The invention relates to medicine, in particular to a method for quantifying the specific bitterness of medicine. Background technique [0002] Most active pharmaceutical ingredients are bitter, and the degree of bitterness can determine people's overall compliance with drugs. Therefore, covering up the bitter taste of drugs and improving people's compliance with drugs is one of the problems that pharmacists must solve. [0003] The prerequisite for conducting drug taste masking research is to establish a scientific, standardized, accurate, and repeatable evaluation method for bitterness. Generally, people’s evaluation of drug bitterness itself is expressed through qualitative descriptions, such as unbearable suffering, a little bitterness, There is almost no bitterness, etc., and lack of objective and quantitative description; the existing quantification methods for bitterness mostly have problems such as inconsistent quantitative standards and narrow scope ...

AI Technical Summary

Problems solved by technology

[0004] For above-mentioned situation, in order to overcome the defective of prior art, the purpose of the present invention is to provide a kind of quantitative method of specific bitterness of medicine, provide reference for the quantitative evaluation of bitterness of medicine, can effectively measure the bitterness of traditional Chinese medicine monomer substance, here The method can effectively solve the problem of lack of objective and quantitative description in the process of evaluating the bitterness of drugs, so as to compare the bitterness of different drugs more accurately and objectively.

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