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Parallel bioreactor system

A bioreactor and control system technology, applied in bioreactor/fermenter combinations, specific-purpose bioreactors/fermenters, biochemical instruments, etc., can solve the problem of high-throughput screening and culture of samples or cell clones. Process optimization, inability to control the microenvironment of the culture container, etc., to achieve the effects of small shear force, increased growth density, and high dissolved oxygen level

Pending Publication Date: 2018-05-11
ZHEJIANG JINYISHENGSHI BIOENG CO LTD
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  • Abstract
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  • Claims
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Problems solved by technology

[0011] According to the preferred embodiment of the present invention, the problem that conventional reactors cannot realize high-throughput screening of samples or cell clones and optimize the culture process can be solved
According to the preferred embodiment of the present invention, the problem that the conventional high-throughput shaker cannot realize the microenvironment control inside the culture vessel can be solved

Method used

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Embodiment Construction

[0048] Embodiments of the present invention will be described below with reference to the drawings. The following descriptions are merely exemplary and are not intended to limit the protection scope of the present invention.

[0049] The parallel bioreactor system according to the embodiment of the present invention is based on the non-bubbling oxygen transfer mechanism. Several culture containers with inverted truncated conical (inverted frustum-shaped) inner chambers are placed on the same platform (shaking plate), and the platform passes The oscillator is driven to realize eccentric oscillation operation. In some embodiments, the parameter control of each culture container can be controlled by an independent CPU and actuator, and data such as records and reports are relatively independent, and the cell culture microenvironment such as pH, dissolved oxygen and nutrients can be precisely regulated. A disposable culture bag with a matching shape and structure is built into th...

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Abstract

The invention provides a parallel bioreactor system. The parallel bioreactor system comprises: an oscillator for generating oscillatory motion; a plurality of culture containers mounted on the oscillator, wherein each culture container has an inner chamber, every inner chamber comprises an upper cylindrical part and a lower inverted frustoconical bottom part, the cross section of the cylindrical part coincides with the top cross section of the inverted frustoconical bottom part, and the bottom of the cylindrical part is connected with the top of the inverted frustoconical bottom part; disposable culture bags arranged in the inner chambers of the culture container and used for accommodating a culture solution, wherein each disposable culture bag has a multifunctional cover plate, the multifunctional cover plates are connected to the tops of the culture bags to seal the culture bags, and the multifunctional cover plates are provided with a plurality of access holes communicating with theinternals of the disposable culture bags; and a control system, wherein the control system controls the oscillatory motion of the oscillator and the parameters of the culture solution in the disposable culture bags.

Description

technical field [0001] The invention provides a parallel bioreactor system and a cultivation method using the parallel bioreactor system. Background technique [0002] The new generation of protein drugs represented by antibodies has attracted more and more attention due to their advantages of good targeting, high curative effect, and small side effects, and has become the mainstream of international biotechnology drug development. In addition, in recent years, the ravages of bird flu, foot-and-mouth disease, swine flu and other diseases require the rapid development and production of a large number of urgently needed vaccines and related biological protein pharmaceutical products in a short period of time. To achieve the rapid production of the above-mentioned related protein drugs, antibodies, and vaccine products, it all depends on the equipment that can truly realize the large-scale cultivation of animal cells-bioreactors. [0003] Bioreactor is a bridge connecting vacc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/36C12M1/34C12M1/00
CPCC12M23/14C12M23/44C12M27/16C12M29/10C12M29/18C12M41/00C12M41/12C12M41/26C12M41/34C12M41/44C12M23/58
Inventor 罗顺胡福林原世平宋金沛
Owner ZHEJIANG JINYISHENGSHI BIOENG CO LTD
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