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Method for preparing hepatitis B Shukang capsules

A technology of Yigan Shukang and capsules, which is applied in the field of preparation of Chinese patent medicines, can solve the problems of low transfer rate and inability to ensure sufficient extraction of active ingredients, and achieve the effect of reducing dosage and improving product efficacy

Active Publication Date: 2018-05-15
SHAANXI DONGKE PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Aiming at the problems existing in the prior art, the object of the present invention is to provide a preparation method of Yigan Shukang Capsules, which solves the problem that the existing extraction process cannot ensure the sufficient extraction of active ingredients so that the transfer rate is low

Method used

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  • Method for preparing hepatitis B Shukang capsules
  • Method for preparing hepatitis B Shukang capsules
  • Method for preparing hepatitis B Shukang capsules

Examples

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Effect test

preparation example Construction

[0087] The raw materials for preparing Yigan Shukang Capsules are: 10-15 parts by mass of Phyllostachys phylloxera, 15-20 parts by mass of Salvia Miltiorrhiza, 15-20 parts by mass of Hedyotis diffusa, 15-20 parts by mass of Astragalus, 15-20 parts by mass of Polygonum multiflorum, Polygonum cuspidatum 15-20 parts by mass, the sum of the parts by mass of raw materials is 100 parts. Its preparation method comprises the following steps:

[0088] Step 1: take Astragalus membranaceus, decoct and extract twice, combine the extracts, filter, and use the dregs for later use, concentrate the filtrate under reduced pressure to a thick paste, and dry it in vacuum to form a fine powder A;

[0089] Step 2: Add the dregs of Step 1 to the herbs of Phyllostachys phylloxera, Salvia, Hedyotis diffusa, Polygonum cuspidatum and Polygonum multiflorum, extract twice with ethanol under reflux, combine the extracts, filter, and recover the ethanol from the filtrate under reduced pressure and concentr...

Embodiment

[0098] The components of Yigan Shukang Capsules in this example are: Phyllostachys foliage 322g, Salvia miltiorrhiza 600g, Hedyotis diffusa 460g, Radix Astragali 460g, Polygonum multiflorum 460g, Polygonum cuspidatum 460g; After purification, they are divided into two groups, which specifically include the following steps:

[0099] Step 1: Take Radix Astragalus and extract twice, add 10 times the amount of water for the first time, add 8 times the amount of water for the second time, each time for 2 hours, combine the two extracts, filter, and set aside the dregs, the filtrate is at -0.04 Mpa, concentrated under reduced pressure at 70°C to a thick paste with a relative density of 1.35-1.45 (60°C), dried in vacuum to fine powder A;

[0100] Step 2: Add the dregs of step 1 to the medicinal materials of Phyllostachys phylloxera, Danshen, Hedyotis diffusa, Polygonum cuspidatum and Polygonum multiflorum, add 70% ethanol to reflux and extract twice, add 12 times the amount for the f...

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Abstract

The invention discloses a method for preparing hepatitis B Shukang capsules. The method comprises the following steps: performing water extraction on radix astragali, concentrating and drying an extract to fine powder A, merging herb residue with phyllanthus urinaria, red sage root, heydyotis, gentrin knotweed, and fleece-flower root, extracting the materials by ethanol with concentration being 70%, concentrating and drying the extract to fine powder B, uniformly mixing the fine powder A and the fine powder B, performing one-step granulation, and placing the product in the capsules to obtain the hepatitis B Shukang capsules. According to the invention, extraction by grouping is employed, the effective components can be enriched, the product curative effect is increased, and a purpose of reducing an administration amount is achieved. Compared with an original technology group, under condition that the administration amount of the prepared hepatitis B Shukang capsules is reduced by 20%,the inhibiting effect of the hepatitis B Shukang capsules for expression effect of HepG2-2.2.15 cells HBsAg and HBeAg and protection effect for chronic liver injury (a CC14 model) is stronger than that of an original technology.

Description

technical field [0001] The invention belongs to the technical field of preparation of Chinese patent medicines, and in particular relates to a preparation method of Yigan Shukang capsules. Background technique [0002] Hepatitis B is a globally recognized major public health problem, which not only seriously affects health but also imposes a heavy burden on individuals and families. It is an infectious disease caused by hepatitis B virus (Hepatitis B virus, HBV), mainly characterized by hepatitis and may cause damage to multiple organs. According to the World Health Organization (WHO) report, there are about 2 billion people who have been infected with HBV in the world, of which 350 million are chronically infected with HBV. There are about 1 million people with hepatocellular carcinoma (Hepatocellular Carcinoma, HCC). There are about 120 million chronic hepatitis B virus carriers in my country, which is the country with the largest number of carriers. Among them, there are ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/748A61K9/48A61P1/16A61P31/20
CPCA61K9/1682A61K36/47A61K36/481A61K36/537A61K36/704A61K36/748A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 夏传涛杜杉王芳
Owner SHAANXI DONGKE PHARMA
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