Medical injection material, preparation method thereof and application of material

A technology of raw materials and components, applied in the medical field, can solve problems such as the risk of disease transmission cannot be ruled out

Inactive Publication Date: 2018-05-15
SHANGHAI CHARTWELL MEDICAL INSTR CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because it needs to be extracted from blood, the potential risk of disease transmission cannot be ruled out, so it has received the attention of clinicians and severely limited its clinical application

Method used

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  • Medical injection material, preparation method thereof and application of material
  • Medical injection material, preparation method thereof and application of material
  • Medical injection material, preparation method thereof and application of material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0126] The preparation method of the submucosal injection material base material in this example is as follows: add 0.8 g of agar, 0.3 g of sodium alginate and 0.9 g of sodium chloride into 100 ml of water, stir and heat to 90° C. to form a clear hydrosol. Then add 10 grams of hydroxyapatite, stir in a 30°C water bath, cool down to 40°C, and let stand to form a white latex-like semi-solid composite hydrogel (FQ).

Embodiment 2-10

[0137] Repeat Example 1, the difference is that in Examples 2-10, each formula in Table 1 is used to replace the formula in Example 1.

[0138] In addition, the medical injection materials prepared in Examples 2-10 were tested with the methods of Test Examples 1 and 2, and the results are listed in Table 2.

[0139] Table 1 Formula of medical injection materials

[0140]

[0141]

[0142] *: The mixing ratio is the weight mixing ratio

[0143] Table 2 Properties of medical injection materials

[0144]

[0145] The above results show that the sols of the above-mentioned injection materials of the present invention are safe and non-toxic, have good viscosity at low concentrations, can form a relatively stable suspension with the filler, and can form a sol within 2-5 minutes after injection. A semi-solid gel with a stable shape, thereby achieving good submucosal injection lifting and surgical assistance effects. The injection material undergoes a state change under cer...

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PUM

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Abstract

The invention discloses a medical injection material which particularly comprises, by weight, 6-12 parts of first components, 1-5 parts of second components and 50-150 parts of third components. The first components are selected from agar, xanthan gum, carrageenan, pectin, gelatin or combination thereof, the second components are selected from alginate, carboxymethyl cellulose sodium, polyvinyl alcohol, polyethylene glycol, polyvinylpyrrolidone, sodium polyaspartate or combination thereof, and the third components are selected from hydroxyapatite, silicon rubber, glass micro-spheres, polypropylene micro-spheres, montmorillonite or combination thereof. Safe and non-toxic hydrosol with good viscosity under low concentration is selected and can form stable suspension liquid together with fillers, semisolid gel with a stable shape can be formed under the condition of a human body after injection, and good submucous injection lifting and surgical auxiliary effects can be achieved.

Description

technical field [0001] The invention relates to the medical field, and more specifically relates to a medical injection material and its preparation method and application. Background technique [0002] Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are minimally invasive techniques for resection of diseased mucosal tissue. At present, it has been used as the first choice for the treatment of early-stage tumors of the digestive tract, and its status is equivalent to surgery and radiotherapy and chemotherapy. Because of its simplicity, less trauma, fewer complications, and reliable curative effect, it has attracted more and more attention from clinicians in various countries. Submucosal injection, as the decisive factor to ensure the safety of EMR and ESD, has become the focus of research. [0003] Submucosal injection is one of the key steps before EMR / ESD resection of the lesion, which refers to injecting a specific liquid into the submucosa ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/14
CPCA61L31/042A61L31/145A61L2400/06C08L5/08C08L5/12
Inventor 甲斐元虎袁志斌
Owner SHANGHAI CHARTWELL MEDICAL INSTR CO LTD
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