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Health-care vagina gel containing complex probiotic ingredient

A technology of compounding probiotics and vaginal gel, which can be used in medical preparations containing active ingredients, medical preparations without active ingredients, and plant/algae/fungus/moss ingredients, etc., and can solve problems such as discomfort and shedding.

Inactive Publication Date: 2018-05-18
王甲林
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Major drawbacks are possible discomfort and dislodgement from the vagina during the treatment period

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Preparation of Lactobacillus rhamnosus fermentation product lysate:

[0034] a, expanding Lactobacillus rhamnosus in the seed culture medium;

[0035] The seed medium formula: 30g of fresh immature fruit pulp of Luo Han Guo, 2g of chitosan deacetylated 99%, 0.5g of Kudingcha extract, 10g of glucose, 15g of peptone, 6g of sodium chloride, 1ml of Tween-80, Dipotassium hydrogen phosphate 1g, magnesium sulfate heptahydrate 0.65g, manganese sulfate monohydrate 0.19g, add water to 1000ml, adjust pH to 6.5, sterilize for later use;

[0036] b. Inoculating the expanded Lactobacillus rhamnosus seeds into the fermentation medium for fermentation to obtain a fermentation liquid;

[0037] Fermentation medium: fresh immature fruit pulp of Luo Han Guo 5%, chitosan 0.5% deacetylated 99%, Kudingcha extract 0.05%, peptone 1%, trehalose 2%, glucose 1.5%, Tween-80 0.1 %, manganese sulfate monohydrate 0.019%, dipotassium hydrogen phosphate 0.2%, magnesium sulfate heptahydrate 0.058%;

...

Embodiment 2

[0046] Preparation of Lactobacillus rhamnosus fermentation product lysate:

[0047] a, expanding Lactobacillus rhamnosus in the seed culture medium;

[0048] The seed medium formula: 50g of fresh immature fruit pulp of Luo Han Guo, 3g of chitosan deacetylated 99%, 1.6g of Kudingcha extract, 10g of glucose, 15g of peptone, 6g of sodium chloride, 1ml of Tween-80, Dipotassium hydrogen phosphate 1g, magnesium sulfate heptahydrate 0.65g, manganese sulfate monohydrate 0.19g, add water to 1000ml, adjust pH to 6.5, sterilize for later use;

[0049] b. Inoculating the expanded Lactobacillus rhamnosus seeds into the fermentation medium for fermentation to obtain a fermentation liquid;

[0050] Fermentation medium: fresh immature fruit pulp of Luo Han Guo 9%, chitosan 0.8% deacetylated 99%, Kudingcha extract 0.05%, peptone 1%, trehalose 2%, glucose 1.5%, Tween-80 0.1 %, manganese sulfate monohydrate 0.019%, dipotassium hydrogen phosphate 0.2%, magnesium sulfate heptahydrate 0.058%;

...

Embodiment 3

[0059] Preparation of Lactobacillus rhamnosus fermentation product lysate:

[0060] a, expanding Lactobacillus rhamnosus in the seed culture medium;

[0061] The seed medium formula: 42g of fresh immature fruit pulp of Luo Han Guo, 2.6g of chitosan deacetylated 99%, 1.2g of Kudingcha extract, 10g of glucose, 15g of peptone, 6g of sodium chloride, and 1ml of Tween-80 , Dipotassium hydrogen phosphate 1g, magnesium sulfate heptahydrate 0.65g, manganese sulfate monohydrate 0.19g, add water to 1000ml, adjust pH to 6.5, sterilize for later use;

[0062] b. Inoculating the expanded Lactobacillus rhamnosus seeds into the fermentation medium for fermentation to obtain a fermentation liquid;

[0063] Fermentation medium: fresh immature fruit pulp of Luo Han Guo 7%, chitosan 0.7% deacetylated 99%, Kudingcha extract 0.05%, peptone 1%, trehalose 2%, glucose 1.5%, Tween-80 0.1 %, manganese sulfate monohydrate 0.019%, dipotassium hydrogen phosphate 0.2%, magnesium sulfate heptahydrate 0.05...

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Abstract

The invention discloses a health-care vagina gel containing a complex probiotic ingredient, which is prepared by the following method: (1) preparation of lactobacillus rhamnosus fermentation product lysate; (2) preparation of gel: contained in per 100ml of gel are: 15ml of sodium alcohol ether sulphate (AES: 98 percent), 0.18g of sodium dodecyl benzene sulfonate, 5ml of glycerol, 0.5g of beta-glucan, 3ml of lactobacillus rhamnosus ferment lysate, 3ml of amur corktree bark extract, 0.1g of citric acid, 1.0g of menthol, 4g of NaCl, 0.5g of preservative and the balance of distilled water for setting volume to 100ml. The gel disclosed by the invention is mild and non-irritating, and can effectively inhibit inflammatory reaction and promote the repair of vagina mucosa injury, and moreover, thegel has a strong inhibiting effect on candida but does not have an obvious inhibiting effect on probiotics existing in the vagina, and can effectively prevent the destruction of the environment in thevagina.

Description

technical field [0001] The invention relates to a health-care vaginal gel, in particular to a health-care vaginal gel containing compound probiotic ingredients. Background technique [0002] Gynecological gel is a kind of gynecological medicine, gel, used for the treatment of various gynecological vaginitis and cervicitis, including: bacterial vaginosis, trichomonal vaginitis, mixed vaginitis, gonococcal infection, chronic cervical Inflammation, cervical erosion. It has anti-inflammatory, bactericidal and antipruritic effects. It has obvious inhibitory effect on the growth of Staphylococcus aureus, Escherichia coli, Neisseria gonorrhoeae, Candida albicans, fungi, yeast and other pathogenic microorganisms. [0003] An ideal vaginal drug sustained-release system should not only be easy to operate, reversible in application, painless to patients, low in cost, wide in sources, and safe and continuous in administration, but also requires the system to release drugs continuously...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/747A61K36/42A61K9/06A61K47/36A61K47/46A61P15/02A61P31/02A61P31/10
Inventor 王甲林
Owner 王甲林
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