Antibodies Against Claudin 18.2 Useful in Cancer Diagnosis

An antibody and antigen technology, applied in the field of antibodies against claudin 18.2 for cancer diagnosis, which can solve problems such as expression limitations
CN108047331AActive Publication Date: 2018-05-18ASTELLAS PHARMA INC +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
ASTELLAS PHARMA INC
Publication Date
2018-05-18

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Abstract

The invention relates to antibodies against claudin 18.2 useful in cancer diagnosis. The invention relates to antibodies directed against an epitope located within the C-terminal portion of CLDN18.2 which are useful, for example, in diagnosing cancer and / or in determining whether cancer cells express CLDN18.2.
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Description

[0001] This application is a divisional application of the Chinese patent application with application number 201380024247.0. The original application is the PCT international application PCT / EP2013 / 001331 filed on May 6, 2013, which entered the Chinese national phase on November 7, 2014. technical field

[0002] The present invention relates to antibodies against claudin 18.2 for use in cancer diagnosis. Background technique

[0003] Claudin is an integral membrane protein located within the tight junction of epithelium and endothelium. Claudin is predicted to have four transmembrane segments, with two extracellular loops, and both N- and C-termini located in the cytoplasm. The claudin (CLDN) family of transmembrane proteins plays a key role in the maintenance of epithelial-endothelial tight junctions and may also play a role in the maintenance of the cytoskeleton and in cell signal transduction.

[0004] The claudin 18 (CLDN18) molecule is an integrated transmembrane prot...

Claims

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