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Method for preparing core-shell structure nanoparticles on basis of coaxial electrostatic spraying shell insertion strategy

A technology of coaxial electrospray and core-shell structure, applied in the field of nanomaterial preparation, can solve problems such as unstable core-shell structure

Inactive Publication Date: 2018-05-18
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The core-shell structure carrier particles prepared by coaxial electrospraying have no chemical bonds between the shell polymer and the core polymer, and the core-shell structure is unstable

Method used

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  • Method for preparing core-shell structure nanoparticles on basis of coaxial electrostatic spraying shell insertion strategy
  • Method for preparing core-shell structure nanoparticles on basis of coaxial electrostatic spraying shell insertion strategy
  • Method for preparing core-shell structure nanoparticles on basis of coaxial electrostatic spraying shell insertion strategy

Examples

Experimental program
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Effect test

Embodiment 1

[0020] A certain amount of hydrophilic polymer PEG (Mn=20000) was weighed, dissolved in the solvent TFE (trifluoroethanol), and a solution with a concentration of 10% was prepared as the shell solution. Weigh a certain amount of hydrophobic polymer PCL (Mn=10000), dissolve it in the solvent TFE (trifluoroethanol), and configure a PCL / TFE solution with a concentration of 6% as the core layer solution; prepare the core shell by coaxial electrospray Structural microspheres. Set the distance between the nozzle and the receiving plate to be 20 cm, and inject the PEG and PCL solutions into the nozzle through two independent syringe pumps. The injection rate of the shell layer was 1.2mL / h, and that of the core layer was 0.3mL / h. Adjust the high-voltage power supply voltage to about 20kV, and at this time, a stable Taylor cone is formed at the bottom of the nozzle. Collect the EFI particles onto tinfoil. The morphology and particle size were characterized by SEM. Take a certain am...

Embodiment 2

[0022] The same method as in Example 1 was used to prepare core-shell microspheres. The shell solution is PEG / TFE, the core solution is PCL / TFE, the injection speed of the fixed shell PEG solution is 1.2mL / h, and the injection speed of the core layer PCL solution is 0.5mL / h, 0.4mL / h , 0.3mL / h, other parameters are all the same as in Example 1. Three groups of core-shell microspheres were prepared by coaxial electrospraying. Take a certain amount of core-shell microspheres prepared by the above method, dissolve them in deionized water, filter, and measure their hydrated particle sizes by DLS.

Embodiment 3

[0024] Weigh a certain amount of hydrophilic polymer PEG (Mn=20000), dissolve it in the solvent TFE (trifluoroethanol), and configure a solution with a concentration of 10% as the shell solution; weigh a certain amount of hydrophobic polymer PLA (Mn=17000) was dissolved in the solvent TFE (trifluoroethanol), and a PLA / TFE solution with a concentration of 6% was prepared as a core layer solution; core-shell microspheres were prepared by coaxial electrospraying. Set the distance between the nozzle and the receiving plate to be 20 cm, and inject the PEG and PCL solutions into the nozzle through two independent syringe pumps. The injection rate of the shell layer was 1.2mL / h, and that of the core layer was 0.3mL / h. Adjust the high-voltage power supply voltage to about 20kV, and at this time, a stable Taylor cone is formed at the bottom of the nozzle. Collect the EFI particles onto tinfoil. The morphology and particle size were characterized by SEM. Take a certain amount of elec...

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Abstract

The invention discloses a method for preparing core-shell structure nanoparticles on the basis of a coaxial electrostatic spraying shell insertion strategy. According to the method, a hydrophilic polymer is weighed and dissolved in a solvent A, and an obtained solution is taken as a shell solution; a hydrophobic polymer is weighed and dissolved in a solvent B, and an obtained solution is taken asa core solution; the solvent A and the solvent B are mutually soluble solvents; core-shell structure microspheres are prepared by a coaxial electrostatic spraying device; the obtained microspheres areplaced in deionized water and filtered, and the core-shell structure nanoparticles are obtained. The core-shell structure nanoparticles prepared with the method have good stability and have the sizestill not changed after being stored for one week; the core-shell structure nanoparticles with different particle sizes can be prepared with the method through changing of the sample injection speed of the core solution.

Description

technical field [0001] The invention belongs to the technical field of nanomaterial preparation, and relates to a method for preparing polymer particles by electrostatic spraying, in particular to a method for preparing nanoparticles with a core-shell structure based on a coaxial electrospray shell insertion strategy. Background technique [0002] In recent years, the application of nanotechnology in the field of tumor therapy has attracted great attention. By utilizing the EPR effect of tumor tissue, the nano-drug delivery system can precisely deliver anti-tumor drugs to the lesion site, and minimize the side effects of anti-tumor drugs while maximizing the therapeutic effect of tumors. Among the numerous nano-drug delivery systems, core-shell micelles formed by self-assembly of amphiphilic polymers have been the most extensively studied. For example, the micelles formed by the amphiphilic polymer PEG-PCL (polyethylene glycol-polycaprolactone) have good biocompatibility an...

Claims

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Application Information

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IPC IPC(8): C08J3/12C08L71/02C08L67/04
CPCC08J3/126C08J2371/02C08J2467/04
Inventor 陈家明王利群王红军柳定荣
Owner ZHEJIANG UNIV
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