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Application of 1,8-naphthyridinyl fluorescent molecular probe in research on neural mechanism of ketamine recreational abuse and diagnosis of addiction degree

A fluorescent probe, ketamine technology, applied in the field of biomedicine, to achieve the effect that is difficult to promote and expensive

Inactive Publication Date: 2020-04-21
KUNMING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The 1,8-naphthyridine group has good biological activity and is sought after by scientific and technological workers in the design and synthesis of drug molecules. It is widely used in anti-tumor, anti-depressant and other drugs, but there is no report using 1,8-naphthyridine as the parent. A fluorescent probe to label Aβ plaques

Method used

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  • Application of 1,8-naphthyridinyl fluorescent molecular probe in research on neural mechanism of ketamine recreational abuse and diagnosis of addiction degree
  • Application of 1,8-naphthyridinyl fluorescent molecular probe in research on neural mechanism of ketamine recreational abuse and diagnosis of addiction degree
  • Application of 1,8-naphthyridinyl fluorescent molecular probe in research on neural mechanism of ketamine recreational abuse and diagnosis of addiction degree

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] The preparation of embodiment 1, C3 compound

[0058] according to figure 2 The synthetic scheme shown prepares the C3 compound.

[0059] step 1:

[0060] Synthesis of 2-amino-5,7-trifluoromethyl-1,8-naphthyridine (compound 1): 2,6-diaminopyridine (commercially available, analytically pure, 10.9g, 0.1mol) and hexafluoroacetyl Acetone (commercially available, analytically pure, 10.0 g, 0.1 mol), 100 mL of phosphoric acid, under nitrogen protection, stirred and refluxed for 24 hours. The reaction solution was cooled, and adjusted to neutrality with ammonia water under ice bath conditions. Refrigerate overnight at 5°C, then filter with suction, wash the filter cake with cold water, and dry to obtain the crude product. The crude product was recrystallized from absolute ethanol to obtain light yellow solid powder. Yield: 17.3g (61.3%).

[0061] Step 2:

[0062] Synthesis of Compound 3: Compound 1 (2.81 g, 0.01 mol) and Compound 2 (0.01 mol) were dissolved in 100 mL o...

Embodiment 2

[0069] Example 2. Application of C3 compound in research on neural mechanism of recreational abuse of ketamine and diagnosis of addiction degree

[0070] Ketamine Abuse SD Rat Model:

[0071] 1. One administration mode and two different dosages were studied in SD rats with administration time of 1 month:

[0072] Model 1: Select 9 healthy Kunming SD rats (male, 6 months old) and inject ketamine intraperitoneally at a dose of (30 mg / kg) for biochemical detection. Body weight was measured weekly and doses were adjusted.

[0073] Model 2: Select 9 healthy Kunming SD rats (male, 6 months old) and inject ketamine intraperitoneally at a dose of (60 mg / kg) for biochemical detection. Body weight was measured weekly and doses were adjusted.

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Abstract

The invention provides an application of 1,8-naphthyridinyl fluorescence molecular probes in the study of entertainment abuse neuromechanism of ketamine and the diagnosis of the addiction level. The study of the in-vivo drug addiction mechanism through using a fluorescence imaging technology is not reported home and abroad, the study of the neuromechanism does not appear in the existing reports ofthe entertainment abuse of the ketamine, and the neuromechanism deduction of entertainment abuse living bodies of the ketamine, treatment target searching and the visual study of the diagnosis of theaddiction level are realized in the invention.

Description

technical field [0001] The invention belongs to the field of biomedicine, and specifically relates to the application of a 1,8-naphthyridinyl fluorescent molecular probe in the research on the neural mechanism of recreational abuse of ketamine and the diagnosis of addiction degree. Background technique [0002] In my country, the number of people who abuse new drugs such as methamphetamine, ketamine, and ecstasy is increasing. Due to the intensification of foreign traditional drugs and new drugs infiltration in Yunnan, drug control and drug rehabilitation work is facing new issues and difficulties. Methadone maintenance therapy cannot be applied to both Detoxification of traditional and new drugs. In order to maintain social stability and unity, it is imminent to develop fast and efficient treatment methods to detoxify new drug abusers as soon as possible, and the research on the neural mechanism of drug abuse will lay the foundation for drug rehabilitation. [0003] As one ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F5/02
CPCA61K49/0021C07F5/022C09K11/06C09K2211/1007C09K2211/1029C09K2211/1055G01N21/6486
Inventor 李慧方洁王尚文解润芳曾晓锋
Owner KUNMING MEDICAL UNIVERSITY