Application of succinic acid and lipoic acid to preparation of anti-stress visceral injury medicine

A technology of visceral injury and succinic acid, which is applied in drug combination and cardiovascular system diseases, etc., can solve the problems of pathological and histological changes of the heart, and achieve the effect of lowering body temperature, preventing and treating gastric injury and heart injury

Inactive Publication Date: 2018-06-01
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] There are many literature reports on gastric stress ulcer and its prevention and treatment. However, there are no literature reports at home and abroad that stress stimuli, such as panic, tension, anxiety and other stimuli, lead to pathological changes in the heart.

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  • Application of succinic acid and lipoic acid to preparation of anti-stress visceral injury medicine
  • Application of succinic acid and lipoic acid to preparation of anti-stress visceral injury medicine
  • Application of succinic acid and lipoic acid to preparation of anti-stress visceral injury medicine

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Embodiment Construction

[0036] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings.

[0037] Stress ulcer is a serious complication characterized by acute gastric private membrane erosion, ulcer and hemorrhage that occurs when the body is under stress such as severe trauma, severe disease and severe psychological disorder, and the mortality rate is as high as 60%. At present, there are many literature reports on gastric stress ulcer and its prevention and treatment. However, there are no literature reports at home and abroad that stress stimuli, such as panic, tension, anxiety and other stimuli, lead to pathological changes in the heart.

[0038] Therefore, the present invention provides the application of succinic acid and / or lipoic acid in the preparation of anti-stress viscera injury medicine, and the viscera includes heart and stomach. Wherein,...

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Abstract

The invention discloses an application of a succinic acid and a lipoic acid to preparation of an anti-stress visceral injury medicine. The viscera comprise heart and stomach. The use level of the succinic acid is 36-110 mg / kg, and the use level of the lipoic acid is 3-30 mg / g. According to the application, the succinic acid is a substance having the central inhibitory effects of being anticonvulsive, calming, lowering the body temperature and easing pain, the lipoic acid, as a strong antioxidant, can effectively eliminate free radicals and chelate transition metals, and exerts the effects effectively in both the water-soluble and fat-soluble environments, and the succinic acid and the lipoic acid have the effects of preventing and treating the stomach injury and the heart injury caused bystress.

Description

technical field [0001] The invention relates to the technical field of anti-stress visceral injury medicines, in particular to the application of succinic acid and lipoic acid in the preparation of anti-stress visceral injury medicines. Background technique [0002] At present, it is believed that stress is a non-specific systemic adaptive response that occurs when the body is stimulated by internal and external environmental factors, social and psychological factors (collectively referred to as stressors), also known as stress response. According to the degree of impact on the body, it is divided into: Physiological stress: refers to the stress that the stressor is not very strong and the action time is short, and it is an important defense for the body against mild and short-term internal and external environmental changes and social and psychological stimuli. Adaptive response (such as sports competition, professional competition, examination, etc.); pathological stress: ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/194A61K31/385A61P43/00A61P9/00
Inventor 臧林泉庄佳毅张业燊
Owner GUANGDONG PHARMA UNIV
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