Antibody assay

A technology of antibodies and autoantibodies, which is applied in the direction of measuring devices, biological testing, material inspection products, etc.
CN108107218AActive Publication Date: 2018-06-01ONCIMMUNE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ONCIMMUNE
Publication Date
2018-06-01

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Abstract

The present invention relates to a method of detecting liver cancer in a mammalian subject by detecting an antibody in a test sample comprising a bodily fluid from the mammalian subject, wherein the antibody is an autoantibody immunologically specific for a tumour marker protein selected from the group consisting of MMP9, AIF1, EpCAM and CDKN1B, which method comprises contacting the test sample with a tumour marker antigen selected from the group consisting of MMP9, AIF1, EpCAM and CDKN1B and determining the presence or absence of complexes of the tumour marker antigen bound to autoantibodiespresent in the test sample where the presence of said complexes is indicative of the presence of liver cancer. Also included within the invention are corresponding methods of diagnosing and treating liver cancer in a mammalian subject, corresponding methods of predicting response to an anti-liver cancer treatment, a corresponding method of detecting an antibody in a test sample comprising a bodilyfluid from a mammalian subject and kits suitable for performing methods of the invention.
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Description

technical field

[0001] The present invention relates generally to the field of antibody detection, and in particular to assays for the detection of liver cancer-associated autoantibodies in samples comprising bodily fluids of patients. Background technique

[0002] Many diagnostic, prognostic and / or monitoring assays rely on the detection of biomarkers of a particular disease state or disease susceptibility. Such biomarkers are typically proteins or polypeptides that are characteristic of a particular disease or associated with disease susceptibility, and are often used to detect cancer, including liver cancer.

[0003] Liver cancer and especially hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and it is also the second most common cause of cancer death. High mortality is caused by late diagnosis (often after metastasis) and pre-existing liver disease. Late diagnosis is due to lack of early symptoms and suboptimal imaging techniques used for diagno...

Claims

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