Medical compositions of cannabidiol, 5-HT2A receptor antagonist and 5-HT reuptake inhibitor and applications of medical compositions
A technology of 5-HT2A and reuptake inhibitors, applied in drug combinations, effective ingredients of hydroxyl compounds, pharmaceutical formulations, etc., can solve problems such as adverse reactions, poor effects, and high possibility of drug interactions, so as to avoid liver damage. damage effect
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Embodiment 1
[0049] Example 1 Synergistic antidepressant effect of SARIs and CBD
[0050] The forced swimming test, also known as the "behavioral despair" test, is a credible animal model of depression and is widely used to screen antidepressant drugs and study the mechanism of action of antidepressant drugs. Numerous studies have shown that the model is sensitive to the vast majority of antidepressants.
[0051] Take 120 healthy Kunming mice, 20-25g. Breeding conditions: 10 birds / cage, room temperature 22±1°C, humidity 50±10%, natural light, free access to food and water. All animals were acclimatized in the feeding environment for 5 days before starting the experiment. Before the experiment, they were fasted for 12-16 hours and had free access to food and water. The above 120 mice were randomly divided into 12 groups according to sex and body weight, 10 in each group, half male and half male: the specific grouping method is:
[0052] The control group was given an equal volume of norm...
Embodiment 2
[0064] Example 2 The adverse reaction effect experiment of the composition of the present invention-mouse body weight change
[0065] Establish a rat model of depression: 60 rats, weighing 180-210 g, were raised in a standard environment (room temperature (22±2)°C, 12h dark, 12h white, lights on at 8:00), free to eat and drink, and drink water.
[0066] Establish chronic stimulation: randomly give rats daily electric shocks to the soles of their feet, fasting, swimming in ice water, water deprivation, heat stimulation, reverse black and white, no stimulation and tail pinch stimulation to establish chronic unpredictable mild stress (CUMS) Rat model of depression, for the next experiment.
[0067] The modeled rats were subjected to a forced swimming test on the 21st day, and the results showed that after 21 days of chronic stimulation, the immobility time of the rats was significantly prolonged, which was significantly different from that before the stimulation (P<0.01); The cl...
Embodiment 3
[0070] Example 3 The adverse reaction effect experiment of the composition of the present invention-liver injury
[0071] A rat model of depression was established according to the method in Example 2.
[0072] Depression rats were randomly divided into 6 groups: positive control model group (with 50% CCl 4 - Edible oil subcutaneous injection induced liver damage in rats); CBD group (200mg / kg, administered for one week); trazodone group (10mg / kg, administered for one week); trazodone+CBD combined group (10:200mg / kg, administered for one week); nefazodone group (10mg / kg, administered for one week); nefazodone+CBD combination group (10:200mg / kg, administered for one week).
[0073] The orbital venous blood of the rats before modeling was taken, and after one week of administration, the orbital venous blood of the rats in each group was taken again, and the plasma was centrifuged for biochemical detection (alanine aminotransferase ALT) determination. The result is as figure ...
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