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Medical compositions of cannabidiol, 5-HT2A receptor antagonist and 5-HT reuptake inhibitor and applications of medical compositions

A technology of 5-HT2A and reuptake inhibitors, applied in drug combinations, effective ingredients of hydroxyl compounds, pharmaceutical formulations, etc., can solve problems such as adverse reactions, poor effects, and high possibility of drug interactions, so as to avoid liver damage. damage effect

Active Publication Date: 2018-06-12
HANYI BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This drug is also suitable for the maintenance treatment of depression and senile depression. The disadvantage is that the drug needs to be taken twice a day, and it has a significant inhibitory effect on CYP3A3 / 4, which may cause drug interactions.
However, due to the sedative and hypnotic effect of CBD, it was found in clinical trials that the most common side effects of CBD in the treatment of mental diseases are diarrhea, weight loss, lethargy, fatigue, etc.
At the same time, it can be learned that the combined application of many drugs at present does not work well, and sometimes serious adverse reactions may occur.

Method used

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  • Medical compositions of cannabidiol, 5-HT2A receptor antagonist and 5-HT reuptake inhibitor and applications of medical compositions
  • Medical compositions of cannabidiol, 5-HT2A receptor antagonist and 5-HT reuptake inhibitor and applications of medical compositions
  • Medical compositions of cannabidiol, 5-HT2A receptor antagonist and 5-HT reuptake inhibitor and applications of medical compositions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1 Synergistic antidepressant effect of SARIs and CBD

[0050] The forced swimming test, also known as the "behavioral despair" test, is a credible animal model of depression and is widely used to screen antidepressant drugs and study the mechanism of action of antidepressant drugs. Numerous studies have shown that the model is sensitive to the vast majority of antidepressants.

[0051] Take 120 healthy Kunming mice, 20-25g. Breeding conditions: 10 birds / cage, room temperature 22±1°C, humidity 50±10%, natural light, free access to food and water. All animals were acclimatized in the feeding environment for 5 days before starting the experiment. Before the experiment, they were fasted for 12-16 hours and had free access to food and water. The above 120 mice were randomly divided into 12 groups according to sex and body weight, 10 in each group, half male and half male: the specific grouping method is:

[0052] The control group was given an equal volume of norm...

Embodiment 2

[0064] Example 2 The adverse reaction effect experiment of the composition of the present invention-mouse body weight change

[0065] Establish a rat model of depression: 60 rats, weighing 180-210 g, were raised in a standard environment (room temperature (22±2)°C, 12h dark, 12h white, lights on at 8:00), free to eat and drink, and drink water.

[0066] Establish chronic stimulation: randomly give rats daily electric shocks to the soles of their feet, fasting, swimming in ice water, water deprivation, heat stimulation, reverse black and white, no stimulation and tail pinch stimulation to establish chronic unpredictable mild stress (CUMS) Rat model of depression, for the next experiment.

[0067] The modeled rats were subjected to a forced swimming test on the 21st day, and the results showed that after 21 days of chronic stimulation, the immobility time of the rats was significantly prolonged, which was significantly different from that before the stimulation (P<0.01); The cl...

Embodiment 3

[0070] Example 3 The adverse reaction effect experiment of the composition of the present invention-liver injury

[0071] A rat model of depression was established according to the method in Example 2.

[0072] Depression rats were randomly divided into 6 groups: positive control model group (with 50% CCl 4 - Edible oil subcutaneous injection induced liver damage in rats); CBD group (200mg / kg, administered for one week); trazodone group (10mg / kg, administered for one week); trazodone+CBD combined group (10:200mg / kg, administered for one week); nefazodone group (10mg / kg, administered for one week); nefazodone+CBD combination group (10:200mg / kg, administered for one week).

[0073] The orbital venous blood of the rats before modeling was taken, and after one week of administration, the orbital venous blood of the rats in each group was taken again, and the plasma was centrifuged for biochemical detection (alanine aminotransferase ALT) determination. The result is as figure ...

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Abstract

The invention discloses compositions, and provides a method for preventing and / or treating depression by using the compositions, and applications of the compositions in preparing medicines for preventing and / or treating depression. The compositions contain cannabidiol, a 5-HT2A receptor antagonist, and a 5-HT reuptake inhibitor or medicinal salt thereof, and also can comprise one or more medicinalcarriers or excipients, wherein the use amount of cannabidiol and the use amount of the 5-HT2A receptor antagonist and the 5-HT reuptake inhibitor or the medicinal salt thereof enable the effect of the composition to be superior to that obtained when the medicines with the corresponding dosages are independently used.

Description

technical field [0001] The invention relates to a composition and its application in preventing and / or treating depression, in particular to a combination of cannabidiol and 5-HT 2A Compositions of receptor antagonists and 5-HT reuptake inhibitors (SARIs) and their use in preventing and / or treating depression. Background technique [0002] Depression is an affective disorder mental disease that seriously affects physical and mental health. It is mainly manifested as obvious and persistent low mood, accompanied by abnormal thinking and behavior. Depression has become a common disease in modern society. Currently, drug therapy is the first choice for the treatment of depression. Several typical antidepressants clinically exert antidepressant effects by increasing the levels of monoamines such as 5-HT and NE. [0003] At present, antidepressants are mainly divided into traditional antidepressants and new antidepressants. Traditional antidepressants refer to monoamine oxidas...

Claims

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Application Information

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IPC IPC(8): A61K31/05A61K31/496A61P25/24
CPCA61K31/05A61K31/496A61K2300/00
Inventor 张可谭昕常坦然金倩
Owner HANYI BIO TECH CO LTD
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