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Zirconia-silica gel liquid-phase chromatographic packing and application thereof

A chromatographic packing and liquid chromatography technology, which is applied in the field of D-fructose-1,6-diphosphate-modified zirconia-silica gel liquid chromatography packing, can solve the problems of poor chemical stability and achieve improved stability and good chromatography The effect of separation performance, good thermal stability and chemical stability

Active Publication Date: 2018-06-12
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, its chemical stability is poor, and it is only suitable for use in the range of pH = 2-8

Method used

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  • Zirconia-silica gel liquid-phase chromatographic packing and application thereof
  • Zirconia-silica gel liquid-phase chromatographic packing and application thereof
  • Zirconia-silica gel liquid-phase chromatographic packing and application thereof

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Embodiment 1

[0025] A D-fructose-1,6-diphosphate-zirconia-silica gel material. The inner and outer surfaces of the porous silica gel microspheres are modified with zirconia to form a zirconia-silica gel matrix. The method reference document (Chinese invention patent, 201510920926.7), wherein the mass fraction of zirconium is 2%, and the specific surface area of ​​the porous silica gel microspheres is 150m 2 / g, the particle size is 5μm, and the pore size is 10nm; the specific surface area of ​​the zirconia-silica gel matrix is ​​140m 2 / g. D-fructose-1,6-diphosphate groups are modified on the surface of the zirconia-silica gel matrix, and the modification process is that the zirconia-silica gel matrix is ​​soaked and stirred in D-fructose-1,6-trisodium diphosphate aqueous solution for 10 hours, The water temperature is 55°C, and the surface-modified zirconia-silica gel chromatography filler of D-fructose-1,6-diphosphate group is obtained. The filler can be used for hydrophilic interactio...

Embodiment 2

[0034] A zirconia-silica gel chromatographic filler, wherein the zirconia-silica gel microspheres adopt the method reported in the literature (Advanced Materials, 2008, 20, 2131–2136), the mass fraction of zirconium is 30%, its particle size is 5 μm, and the pore size is 8 nm , the specific surface area is 350m 2 / g. The zirconia-silica gel matrix is ​​soaked and stirred in D-fructose-1,6-diphosphate trisodium aqueous solution for 10 hours, the water temperature is 55°C, and the surface is modified with D-fructose-1,6-diphosphate group. Zirconia-silica gel chromatography filler . The filler can be used for hydrophilic chromatographic separation.

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Abstract

The invention discloses zirconia-silica gel liquid-phase chromatographic packing. According to the packing, the surface of a zirconia-silica gel matrix is modified with D-fructose-1,6-bis(dihydrogen phosphate). Compared with the conventional adenosine monophosphate modified zirconia-silica gel chromatographic packing, the packing provided by the invention has a better chromatographic separation property under a hydrophilic action mode. Compared with the prior silica-gel-matrix liquid-phase chromatographic packing, the material provided by the invention has good chemical stability, can be stably used in a pH range of 1-14, and has a better application prospect.

Description

technical field [0001] The invention relates to the field of liquid chromatography, in particular to a D-fructose-1,6-diphosphate-modified zirconia-silica gel liquid chromatography filler and an application thereof. Background technique [0002] Zirconia-silica gel microspheres have good thermal and chemical stability, and they have important application value in chromatographic separation and sample pretreatment (H.Dun, et al.Anal.Chem.76(2004)5016; Q . Wu, et al. Anal. Chem., 86 (2014) 10122). However, the surface of zirconia is rich in Lewis acidic sites, which leads to strong adsorption of some acidic substances on its surface, which makes it unsuitable for the separation of acidic compounds such as benzoic acid and benzenesulfonic acid (Q.Wang et al., Talanta, 129( 2014) 438). Aiming at this kind of problem, someone has invented a zirconia-silica gel liquid chromatography packing modified by adenosine monophosphate, but the chromatographic column efficiency of this ty...

Claims

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Application Information

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IPC IPC(8): B01J20/283B01D15/08C07B63/00
CPCB01D15/08B01J20/283B01J2220/46B01J2220/52B01J2220/54C07B63/00
Inventor 宋志花关亚风
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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