Microfluidic chip for high-throughput enrichment of micron particles

Abstract

The invention discloses a micro-fluidic chip for enriching micrometer particles at a high flux. The micro-fluidic chip is provided with an enrichment module, an inner outlet collecting module, a drainage module, an outer outlet collecting module and a flow control module which are sequentially stacked from top to bottom; a sample inlet is formed in the center of the enrichment module; the sample inlet communicates with an inertial concentration flow channel; the inertial concentration flow channel communicates with a furcated flow channel; the furcated flow channel communicates with an inner outlet and an outer outlet; the inner outlet collecting module is used for collecting a blank solution at the inner outlet of the enrichment module into the middle; the drainage module is used for draining the blank solution collected by the inner outlet collecting module to a side; the outer outlet collecting module is used for collecting a concentrated solution at the outer outlet to the middle;and the flow control module is used for guiding the blank solution and the concentrated solution after limiting the flow resistances of the blank solution and the concentrated solution. The micro-fluidic chip is high in concentration efficiency, capable of meeting the enrichment demand of a sample solution with extremely-low concentration or large volume, wide in application range, simple in production, low in cost and simple in operation during use.

Description

technical field [0001] The invention relates to an enrichment chip, in particular to a high-throughput enrichment microfluidic chip for micron particles. Background technique [0002] Nowadays, microparticle enrichment technology is almost ubiquitous, and has become an important sample pretreatment link in many industries such as biological research, chemical analysis, environmental testing and medical diagnosis. [0003] At present, the main methods of particle enrichment are centrifugation and pore filtration. The centrifugation method mainly makes the particles in the solution settle by high-speed rotation, and then pours off the supernatant to obtain the enrichment solution. This method often requires expensive instruments, which makes it impossible to use it in the wild or in remote and impoverished areas. At the same time, high-speed centrifugation will inevitably cause damage to flexible biological samples with extremely dilute concentrations. Compared with the high...

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Problems solved by technology

[0004] Purpose of the invention: The present invention provides a microfluidic chip for high-throughput enrichment of micron particles, which solves the problem of low concentration efficiency of existing particle enrichment methods, which cannot meet the enrichment requirements of extremely low concentration or large-volume sample liquids, and has a narrow application range. Inconvenient to operate

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