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Colorant adding technology applied to medical active pulvis, and uniformly-colorized medical active pulvis

A uniform dyeing and dyeing agent technology, applied in the field of medical active powder, can solve the problems of increased dyeing agent, uneven distribution of dyeing agent, and difficulty in ensuring the uniformity of dyeing agent distribution.

Active Publication Date: 2018-06-15
SAIKE SAISI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the freeze-drying method is a slow solvent sublimation process, it often leads to the gradual increase of the dyeing agent from the top layer to the bottom layer, resulting in uneven distribution of the dyeing agent in the final powder.
[0005] It is more difficult to ensure the uniformity of dyeing agent distribution in the powder obtained by simple physical stirring method

Method used

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  • Colorant adding technology applied to medical active pulvis, and uniformly-colorized medical active pulvis
  • Colorant adding technology applied to medical active pulvis, and uniformly-colorized medical active pulvis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] This embodiment provides a uniformly dyed medical active powder, specifically uniformly dyed polylactic acid powder, which is prepared according to the following coloring agent addition process:

[0046] Weigh 10g of polylactic acid (PLA, weight average molecular weight 70KD) as a medical active powder and dissolve it in 100g of toluene (the first good solvent) to prepare a medical active powder solution.

[0047] Weigh 0.005g of β-carotene (medical dye) and dissolve it in 0.5g of chloroform (the second good solvent) to prepare a medical dye solution.

[0048] Mix the two solutions of the medical active powder solution and the medical dye solution, and stir evenly to form a mixed solution.

[0049] Transfer the mixed solution to a one-necked bottle, connect it to a rotary evaporator, turn on the vacuum system and the low-temperature cooling circulation system, and concentrate by rotary evaporation at 25±5°C.

[0050] When the remaining liquid in the one-necked bottle i...

Embodiment 2

[0053] This embodiment provides a uniformly dyed medical active powder, specifically a uniformly dyed two-arm polyethylene glycol-thiol powder, which is prepared according to the following coloring agent addition process:

[0054] Weigh 10g of two-arm polyethylene glycol-thiol (2-arm-PEG-SH, weight-average molecular weight 10KD) and dissolve it in 120g n-butanol (the first good solvent) as a medical active powder, and reinforce it with 0.22 μm nylon Membrane filtration, prepared into medical active powder solution.

[0055] Weigh 0.002g of butyl hydroxyanisole (BHA) as the medical active powder and dissolve it in 10g of ethanol (the first good solvent) to obtain the second medical active powder solution.

[0056] Weigh 0.015g of bright green (medical dye) and dissolve it in 5g of propylene glycol (the second good solvent), filter it with a 0.22 μm nylon reinforced filter membrane, and prepare a medical dye solution.

[0057] Mix the medical active powder solution and the medi...

Embodiment 3

[0062] This embodiment provides a uniformly dyed medical active powder, specifically a uniformly dyed four-armed polyethylene glycol-N-hydroxysuccinimide-glutarate powder, which is prepared according to the following dyeing process:

[0063] Four-arm polyethylene glycol-N-hydroxysuccinimide-glutarate (4-arm-PEG-SG, weight-average molecular weight 20KD) was weighed to prepare a medical active powder solution.

[0064] Weigh 0.01g of Brilliant Blue as a medical dye and dissolve it in 5g of ethanol (the second good solvent) to prepare a medical dye solution.

[0065] The two solutions were mixed and transferred to a one-necked bottle, connected to a rotary evaporator, turned on the vacuum system and low-temperature cooling circulation system, and concentrated by rotary evaporation at 25±5°C.

[0066] When the remaining liquid in the one-necked bottle is about 8% of the volume of the original mixed solution, add 150 g of anhydrous ether (poor solvent) under stirring, and continue ...

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Abstract

The invention relates to the field of synthesis technologies, and discloses a colorant adding technology applied to a medical active pulvis, and a uniformly-colorized medical active pulvis. The colorant adding technology applied to the medical active pulvis comprises the following steps: respectively dissolving the medical active pulvis and a medical colorant in good solvents, uniformly mixing theobtained solutions according to a certain ratio, slowly adding the obtained solution into a poor solvent while mechanically stirring the poor solvent to precipitate the active pulvis and the colorant, and drying the obtained colorized active pulvis in a proper way. The colorant adding technology is widely applied to addition of colorants to active pulvis in the fields of medicines and medical instruments. The colorant adding technology allows the uniformly-colorized medical active pulvis to be very efficiently obtained without negatively affecting the active components of the pulvis.

Description

technical field [0001] The invention relates to the field of synthesis technology, and in particular to a dyeing agent addition process applied to medical active powders and uniformly dyed medical active powders. Background technique [0002] At present, it is known that dyes are mostly used in the field of fiber textiles or protein detection, and dyes are rarely added to medical powders or granules, and the effect of dyes added to medical powders or granules is not ideal. The existing commonly used methods of adding dyes to powders include spray-drying, freeze-drying, etc., and even simple physical stirring methods are used for adding. [0003] The spray drying method is divided into pressure spray drying method, centrifugal spray drying method and airflow spray drying method. They all disperse the material solution to be dried into mist particles through mechanical action, contact with hot air, and instantly remove the solvent to obtain the material. powder. The spray-dr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/215C08L67/04C08L71/02C08L29/04C08L5/08C08L1/28C08L89/00C08L69/00
CPCC08J3/215C08J2301/28C08J2305/08C08J2329/04C08J2367/04C08J2369/00C08J2371/02C08J2389/00
Inventor 董芳芳苑康见孔凡照邓凤娟赵艳李正强王炜徐艳丽
Owner SAIKE SAISI BIOTECH CO LTD