Composite marker for detecting esophagus cancer and application thereof

A marker, esophageal cancer technology, applied in the field of biomedicine, can solve the problems of patient discomfort and slow speed

Inactive Publication Date: 2018-06-22
上海阿趣生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the examination of esophageal cancer is mainly through double-contrast esophageal barium meal X-ray film and fiber esophagoscopy. These methods make patients feel very uncomfortable, and the judgment is perceptual and slow.

Method used

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  • Composite marker for detecting esophagus cancer and application thereof

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Embodiment

[0015] see figure 1 , the invention is based, at least in part, on the discovery of markers associated with the development of esophageal cancer and with response to treatment in subjects with esophageal cancer. Accordingly, the present invention provides methods and kits for predicting whether a subject has or will develop esophageal cancer by measuring and identifying specific marker combinations.

[0016] Accordingly, the present invention provides the combined markers sarcosine, 1-3 diaminopropane, 3-aminoisobutyric acid, thymine putrescine, cytidylic acid for use in determining whether a subject has or will develop esophageal cancer.

[0017] In another aspect, the invention provides methods for inhibiting the development of esophageal cancer in a subject. The method includes administering to the subject an effective amount of an agent that modulates the expression and / or activity of various markers of the present invention, thereby inhibiting the development of esophage...

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Abstract

The invention provides a composite marker for determining whether a subject has or is about to have esophagus cancer. The composite marker is composed of sarcosine, 1,3-diaminopropane, 3-aminoisobutyric acid, thymidine putrescine and cytidylic acid, and has diagnosis sensitivity of 93.3% and specificity of 0%.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a combined marker for esophageal cancer. Background technique [0002] A biomarker is an indicator that can objectively measure and evaluate normal biological processes, pathological processes, or responses to drug interventions. It is also an important early warning indicator when organisms are damaged. Changes, abnormal performance of physiological activities, abnormal changes of individuals, groups or the entire ecosystem, etc. [0003] Esophageal cancer is a common digestive tract tumor, and about 300,000 people worldwide die from esophageal cancer every year. Its morbidity and mortality vary widely from country to country. my country is one of the areas with high incidence of esophageal cancer in the world, with an average of 150,000 deaths per year, which has aroused widespread concern. At present, the examination of esophageal cancer is mainly through double-contrast esophage...

Claims

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Application Information

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IPC IPC(8): G01N33/574
Inventor 邓军亮楼格尔吴洪强
Owner 上海阿趣生物科技有限公司
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