A human NK cell line

A technology of NK cells and cell lines, applied in the field of cell lines, can solve the problems of difficulty in purifying NK cells, and achieve the effect of strong anti-tumor activity
CN108220236BActive Publication Date: 2020-06-30INST OF GENETICS & DEVELOPMENTAL BIOLOGY CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
INST OF GENETICS & DEVELOPMENTAL BIOLOGY CHINESE ACAD OF SCI
Publication Date
2020-06-30

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Abstract

The invention relates to the cell line, and specifically relates to a NK cell line of the human. The conservation number is CGMCC No. 14891. The NK cell line of the human provided by the invention canbe passaged for a long time and greatly amplified, and has stronger anti-tumor activity, and provides a new experimental model for deeply development chronic activity EBV infectious disease mechanismresearch, screening chronic activity EBV infection, treatment medicine of EBV related lymphocytosis and the like, natural killer cell anti-tumor action mechanism and clinic adoptive immunity treatment for a researcher.
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Description

technical field

[0001] The present invention relates to cell lines, in particular to a human NK cell line. Background technique

[0002] Natural killer cells (NK cells) are important immune cells in the body, which have anti-tumor, anti-viral infection and immune regulation functions.

[0003] NK cells have long been considered an excellent weapon for killing cancer cells and treating infections. However, there are certain difficulties in the purification and large-scale expansion of NK cells in vitro. Therefore, scientists try to establish cell lines and use allogeneic NK cells for tumor biotherapy. Foreign scientists have successively established HANK, KHYG-1, NK-92, NKL, PLT, MOTN, IMC-1, NK-YS, KAI3, SNK -1, SNK6, YT, NK3.3, etc., as well as transgenic NK cell lines such as NK-92MI, IL-2 / NKL, IL-2 / NK3.3 obtained by stably transfecting IL-2. In particular, the establishment of NK-92 has promoted its application in tumor adoptive immunotherapy, and provided powerful res...

Claims

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