Circulating tumor cell assay instrument comprising micro-fluidic chip

Abstract

The invention discloses a circulating tumor cell assay instrument comprising a micro-fluidic chip, which further comprise a sample injection, a liquid collector, a signal acquisition and analysis system, a core controller, and a display control interface, the core controller is electrically connected to the sample injection, the signal acquisition and analysis system and the display control interface to control operation, the sample injection system is connected to the sample inlet of the micro-fluidic chip to drive a sample into the chip according to an instruction of the core controller, theliquid collector is connected to the sample outlet of the micro-fluidic chip to collect enriched target liquid and waste liquid, the signal acquisition and analysis system acquires and analyzes an electric response signal induced by the impedance change of a region with detection electrodes according to an instruction of the core controller, and the display control interface displays a data result according to an instruction of the core controller. The circulating tumor cell assay instrument does not need to mark cell, the processing throughput is high, high-purity living circulating tumor cells can be automatically separated out, the testing process is simple, the efficiency is high, and the application range is wide.

Description

technical field [0001] The invention relates to a cell enrichment instrument, in particular to a circulating tumor cell detection instrument including a microfluidic chip. Background technique [0002] Modern medical research has shown that tumor cells that infiltrate from the original lesion into the peripheral blood circulation, that is, circulating tumor cells, are the "seeds" that cause cancer metastasis. Therefore, circulating tumor cells have important clinical diagnosis and scientific research value, which are mainly reflected in: (1) The detection of circulating tumor cells in blood has higher accuracy than traditional diagnostic techniques such as imaging, which can provide a basis for early diagnosis and prognosis evaluation of cancer; The new approach is called liquid biopsy technology. (2) With the same genetic information as the original tumor, it can provide important samples for the study of cancer metastasis mechanism and the screening of anticancer drugs. ...

AI Technical Summary

Problems solved by technology

[0004] Purpose of the invention: The present invention provides a circulating tumor cell detection instrument including a microfluidic chip, which solves the problems that existing instruments need to label cells, have low processing throughput, high detection cost, and few applicable diseases

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