Traditional Chinese medicinal composition for treating Alzheimer's disease as well as preparation method and application thereof

Abstract

The invention discloses a traditional Chinese medicinal composition for treating the Alzheimer's disease as well as a preparation method and application thereof. The traditional Chinese medicinal composition selects a traditional Chinese medicinal composition prepared from total 18 medicinal materials of national medicines semen nelumbinis, radix asparagi, rhizoma menispermi, rhizoma paris, radixlithospermi, radix sanguisorbae, rhizoma arisaematis, radix platycodonis, rhizoma belamcandae, myrrh, cortex moutan, rhizoma seu radix notopterygii, pericarpium zanthoxyli, caulis trachelospermi, caulis spatholobi, rhizoma cyperi, pericarpium citri reticulatae viride and fructus amomi rotundus; the treatment to a mouse model suffered from the Alzheimer's disease is developed; shown by a result, the traditional Chinese medicinal composition provided by the invention has obvious comprehensive treatment effect on the Alzheimer's disease and moreover has no side effect. The traditional Chinese medicinal composition is proposed to provide a novel technical means for the treatment of the Alzheimer's disease; the huge economic benefit and social benefit can be generated, and the application prospect is quite wide.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and its preparation method and application, in particular to a traditional Chinese medicine composition for treating Alzheimer's disease, its preparation method and application. The invention belongs to the technical field of traditional Chinese medicine. Background technique [0002] Alzheimer's disease is one of the common progressive, senile, neurological and degenerative diseases, which will seriously endanger the life and health of people all over the world, and Alzheimer's disease is mostly manifested as Abnormal protein aggregation, inflammatory response, blood-brain barrier (BBB) ​​permeability changes, oxidative stress response, neuron dysfunction, and signal pathway disturbance in brain tissue in the body's brain tissue. [0003] At present, the pathogenesis of Alzheimer's disease is still unclear, and its mainstream theory is Aβ protein theory, Aβ protein and inflammatory m...

AI Technical Summary

Problems solved by technology

In fact, the abnormal accumulation of Aβ protein can also cause the abnormal activation of microglia and astrocytes in the brain tissue of the body, and further promote the production of more inflammatory mediators by microglia and astrocytes, such as interleukin -1β (Interleukin-1β, IL-1β), tumor necrosis factor-α, these inflammatory mediators IL-1β, TNF-α, IL-6, etc. will continue to aggravate the inflammatory response of the body's brain tissue, and then have a negative effect on Alzheimer's disease. patients pose greater harm

Images