Traditional Chinese medicinal composition for treating Alzheimer's disease as well as preparation method and application thereof
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A technology for Alzheimer's disease and a composition, applied in the field of traditional Chinese medicine, can solve the problems of the harm of Alzheimer's disease patients, the abnormal activation of microglia and astrocytes, and the aggravation of the inflammatory response of the body's brain tissue, etc. Achieve huge economic and social benefits, obvious effects and broad application prospects
Inactive Publication Date: 2018-07-10
QIQIHAR MEDICAL UNIVERSITY
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In fact, the abnormal accumulation of Aβ protein can also cause the abnormal activation of microglia and astrocytes in the brain tissue of the body, and further promote the production of more inflammatory mediators by microglia and astrocytes, such as interleukin -1β
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Embodiment 1
[0042] The preparation of embodiment 1 Chinese medicine composition
[0043] The traditional Chinese medicine composition is composed of the following raw materials by weight: 10.5g of lotus seeds, 10.5g of Tianmen, 6g of bean root, 6.5g of fleas, 9g of comfrey, 12g of Burnet, 6g of Araceae, 6.5g of Platycodon grandiflora, 5.75g of shegan , Myrrh 10g, Cortex Moutan 12.5g, Notopterygium 17.5g, Chuanjiao 3.5g, Spathiphyllum 10.5g, Caulis Spatholobus 12.5g, Rhizoma Cyperus 12.5g, Green Peel 6.5g and Cardamom 4.5g.
Embodiment 2
[0044] The preparation of embodiment 2 Chinese medicine composition
[0045] The traditional Chinese medicine composition is composed of the following raw materials by weight: 5g of lotus seeds, 15g of Tianmen, 3g of bean root, 3g of fleas, 5g of comfrey, 15g of Burnet, 5g of Araceae, 5g of Campanulaceae, 5g of Shegan, 8g of myrrh, Cortex Moutan 15g, Notopterygium 15g, Sichuan Pepper 4g, Spathiphyllum 10g, Caulis Spatholobus 13g, Cyperus Cyperi 12g, Qingpi 7g, Cardamom 4g.
Embodiment 3
[0046] The preparation of embodiment 3 Chinese medicine composition
[0047] The traditional Chinese medicine composition is composed of the following raw materials by weight: 15g of lotus seeds, 5g of Tianmen, 10g of bean root, 8g of fleas, 12g of comfrey, 5g of Burnet, 2g of Araceae, 3g of Campanulaceae, 10g of Shegan, 15g of myrrh, Cortex Moutan 5g, Notopterygium 20g, Sichuan Pepper 2g, Spathiphyllum 12g, Caulis Spatholobus 8g, Cyperus Cyperi 10g, Green Peel 10g, Cardamom 6g.
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Abstract
The invention discloses a traditional Chinese medicinal composition for treating the Alzheimer's disease as well as a preparation method and application thereof. The traditional Chinese medicinal composition selects a traditional Chinese medicinal composition prepared from total 18 medicinal materials of national medicines semen nelumbinis, radix asparagi, rhizoma menispermi, rhizoma paris, radixlithospermi, radix sanguisorbae, rhizoma arisaematis, radix platycodonis, rhizoma belamcandae, myrrh, cortex moutan, rhizoma seu radix notopterygii, pericarpium zanthoxyli, caulis trachelospermi, caulis spatholobi, rhizoma cyperi, pericarpium citri reticulatae viride and fructus amomi rotundus; the treatment to a mouse model suffered from the Alzheimer's disease is developed; shown by a result, the traditional Chinese medicinal composition provided by the invention has obvious comprehensive treatment effect on the Alzheimer's disease and moreover has no side effect. The traditional Chinese medicinal composition is proposed to provide a novel technical means for the treatment of the Alzheimer's disease; the huge economic benefit and social benefit can be generated, and the application prospect is quite wide.
Description
technical field [0001] The invention relates to a traditional Chinese medicine composition and its preparation method and application, in particular to a traditional Chinese medicine composition for treating Alzheimer's disease, its preparation method and application. The invention belongs to the technical field of traditional Chinese medicine. Background technique [0002] Alzheimer's disease is one of the common progressive, senile, neurological and degenerative diseases, which will seriously endanger the life and health of people all over the world, and Alzheimer's disease is mostly manifested as Abnormal protein aggregation, inflammatory response, blood-brain barrier (BBB) permeability changes, oxidative stress response, neuron dysfunction, and signal pathway disturbance in brain tissue in the body's brain tissue. [0003] At present, the pathogenesis of Alzheimer's disease is still unclear, and its mainstream theory is Aβ protein theory, Aβ protein and inflammatory m...
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