1,4-dihydro-3,5-lauryl alcohol ester diacetate-2,6-dimethyl pyridine synthesis method

A technology of lutidine and a synthesis method, which is applied in the field of 1,4-dihydropyridine derivative synthesis, can solve the problems of large environmental pollution, low reaction yield and product purity, and is difficult to store, and achieves reduction of production cost, The effect of high reaction yield and product purity
CN108299286AActive Publication Date: 2018-07-20CHANGZHOU YONGHE FINE CHEM
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHANGZHOU YONGHE FINE CHEM
Publication Date
2018-07-20
Patent Text Reader

Abstract

The invention discloses a 1,4-dihydro-3,5-lauryl alcohol ester diacetate-2,6-dimethyl pyridine synthesis method. The 1,4-dihydro-3,5-lauryl alcohol ester diacetate-2,6-dimethyl pyridine synthesis method comprises the following specific steps: 1, enabling lauryl alcohol and methyl acetoacetate to react to obtain n-dodecyl acetoacetate; 2, enabling the n-dodecyl acetoacetate to react with urotropinor formaldehyde and ammonium acetate to obtain the 1,4-dihydro-3,5-lauryl alcohol ester diacetate-2,6-dimethyl pyridine. The synthesis method uses the lauryl alcohol and the methyl acetoacetate to react to obtain the n-dodecyl acetoacetate, the production of amine wastewater is avoided compared with the reaction between the laurinol and ketene dimer, so that the synthesis method is a green production process, the problem of instability of the reaction material is also solved, and particularly, the synthesis method is higher in reaction yield and production purity and is suitable for industrialproduction.
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Description

technical field

[0001] The invention belongs to the technical field of synthesis of 1,4-dihydropyridine derivatives, and in particular relates to a synthesis method of 1,4-dihydro-3,5-diacetate lauryl-2,6-lutidine. Background technique

[0002] 1,4-dihydro-3,5-diacetate lauryl-2,6-lutidine (also known as 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Didodecanyl acid, CAS No. 36265-41-5, molecular formula C 33 h 59 NO 4 ) is an antioxidant with excellent performance, mainly used in PVC, PE and other plastics.

[0003] At present, the method of synthesizing the compound is to first react lauryl alcohol (also known as lauryl alcohol) with diketene in the presence of amine catalysts to obtain n-dodecyl acetoacetate, and then react with urotropine or formaldehyde and amines Substances (ammonia / ammonium acetate / ammonium bicarbonate, etc.) are reacted.

[0004] The disadvantages of this method are: (1) diketene has a strong lachrymatory property, and is extremely volatile...

Claims

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