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Preparation for treating synovitis and preparation method thereof

A technology for synovitis and preparation, applied in the field of medicine, can solve the problems of short residence time and low release rate, and achieve the effects of long sustained release time, good stability and easy availability of raw materials

Active Publication Date: 2018-07-24
武汉百纳礼康生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The meloxicam compound of the present invention has better solubility, but its residence time in the body is shorter and the release rate is lower

Method used

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  • Preparation for treating synovitis and preparation method thereof
  • Preparation for treating synovitis and preparation method thereof
  • Preparation for treating synovitis and preparation method thereof

Examples

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Embodiment 1

[0042] A preparation for treating synovitis, comprising the following components in percentage by weight: 0.4% meloxicam, 20% soybean phosphatidylcholine, 60% glyceryl dioleate, 7.6% poloxamer 407, 12% ethanol.

[0043] A preparation method for a preparation for treating synovitis, wherein each material is weighed according to the above parts by weight, and the preparation steps are as follows:

[0044] S1. Add glycerol dioleate to soybean phosphatidylcholine, heat and mix in a metal bath at 50°C to make a mixed solution A;

[0045] S2. Add ethanol to the poloxamer 407, heat in a metal bath at 50°C to completely dissolve the poloxamer 407, and prepare a mixed solution B;

[0046] S3. Put meloxicam through a 100-mesh sieve and add it to the mixed solution B prepared by S2, and use a vortex to disperse the meloxicam evenly; then add it to the mixed solution A prepared by S1, and place it in a metal bath at 50°C After heating, use a vortex to disperse and mix evenly; repeat the...

Embodiment 2

[0049] This embodiment is basically the same as Embodiment 1, the difference lies in the following aspects:

[0050] A preparation for treating synovitis, comprising the following components by weight percentage: 1% meloxicam, 60% soybean phosphatidylcholine, 20% glyceryl dioleate, 7% poloxamer 407, 12% ethanol.

Embodiment 3

[0052] This embodiment is basically the same as Embodiment 1, the difference lies in the following aspects:

[0053] A preparation for treating synovitis, comprising the following components in percentage by weight: 0.6% meloxicam, 30% soybean phosphatidylcholine, 50% glyceryl dioleate, 7.4% poloxamer 407, 12% ethanol.

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PUM

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Abstract

The invention discloses a preparation for treating synovitis and a preparation method thereof. The preparation for treating synovitis is prepared from the following components in percentage by weight:0.4%-1% of meloxicam, 20%-60% of phospholipid, 20%-60% of glyceride, 1%-15% of non-ionic surfactant and 1%-20% of cosolvent. The preparation for treating synovitis provided by the invention has goodstability, the meloxicam serving as an effective component can be slowly released lastingly in the human body, the human body can lastingly absorb the medicine for a long time, and the medicine can act in the human body for a long time, so that the treatment effect is better and the bioavailability of the medicine is higher.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a preparation for treating synovitis and a preparation method thereof. Background technique [0002] Synovial joints are where the joint bones touch each other. Between bones forms the synovial joint cavity, which is lined with a membrane called the synovium. The synovium is rich in blood vessels and sensory nerve endings, and has rich blood supply. Synovial cells secrete synovial fluid on the surface to keep the articular cartilage surface lubricated, provide nutrition for the cartilage, and diffuse the heat generated during joint movement. Acute trauma causes synovial hyperemia , Bleeding, swelling and exudation, resulting in a large amount of blood accumulation, increased exudate in the joint, increased pressure in the joint, hindered the circulation of the lymphatic system, gradually accumulated metabolites in the joint, and changed the internal environment of t...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K47/24A61K47/14A61K47/36A61K47/26A61K47/20A61K47/10A61K31/5415A61P19/04A61P19/02
CPCA61K9/0019A61K9/08A61K31/5415A61K47/10A61K47/14A61K47/20A61K47/24A61K47/26A61K47/36
Inventor 罗亮黄丽萍张一漪孟凡玲
Owner 武汉百纳礼康生物制药有限公司
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