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Detection method suitable for traditional Chinese medicine suspension system

A detection method and system technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve problems such as difficult cleaning and easy blockage of filter devices, achieve the effect of simple and fast operation, and improve prediction accuracy

Active Publication Date: 2018-07-24
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to overcome the problem that a filter device needs to be installed during online near-infrared detection in the prior art, and the filter device is easy to be blocked and difficult to clean, and to provide a method that does not require pretreatment of samples and has high prediction accuracy. On-line Mid-infrared Quantitative Analysis Method of Traditional Chinese Medicine Suspension System

Method used

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  • Detection method suitable for traditional Chinese medicine suspension system
  • Detection method suitable for traditional Chinese medicine suspension system
  • Detection method suitable for traditional Chinese medicine suspension system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] 1. Collection of samples

[0044] According to the desorption process of ginkgo diterpene lactone, 10 different batches (Z160104, Z160115, Z160125, Z160205, Z160214, Z160223, Z160302, Z160312, Z160322, Z160401) samples of the desorption process were prepared.

[0045] 2. Spectrum acquisition

[0046] Turn on the MIR host, and after warming up for 30 minutes, set the spectral acquisition parameters as follows: The initial wavenumber of spectral scanning is 650cm -1 , end wavelength 3000cm -1 , wave number increment 4cm -1 , the number of scans is 256 times. The sample does not need to be processed and is directly used to scan the MIR spectrum. Each sample is measured 3 times in parallel, and the average spectrum of the 3 spectra is used for model building. For the MIR spectrum of the desorption solution, see figure 1 .

[0047] 3. Assay

[0048] 3.1 Preparation of reference solution

[0049] Accurately weigh 10.068mg of reference substances ginkgolide A (GA, purit...

Embodiment 2

[0077] After identifying abnormal samples and screening representative samples, the original experimental data were reprocessed using different spectral preprocessing methods and automated band screening methods based on the MATLAB (R2012a, Mathwork Inc., USA) platform. Basically the same as in Example 1, the model optimization adopts the following method:

[0078] Effective spectral preprocessing can eliminate spectral noise and interference, obtain effective model building information, and improve model robustness. Commonly used preprocessing methods are: ①Savitzky-Golay smoothing (Savitzky-Golay smoothing, S-G smoothing); ②Normalization; ③Savitzky-Golay smoothing plus first-order derivatives (Savitzky-Golay smoothing plus first-order derivatives, S-G 1st); Golay smoothing combined with second-order derivatives (Savitzky-Golay smoothing plus second-order derivatives, S-G 2nd) ⑤ Baseline correction; ⑥ Multiplicative scatter correction (MSC); ⑦ Standard normal variate transfor...

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Abstract

The invention relates to a detection method suitable for a traditional Chinese medicine suspension system. The detection method comprises the steps: performing mid-infrared spectrum scanning on a traditional Chinese medicine suspension system sample, collecting spectrum data in an online mode, collecting the traditional Chinese medicine suspension system sample and obtaining test values of ingredient contents in the sample; performing model parameter optimization on the collected spectrum data and the test values; choosing an optimal modeling method according to the optimized model data to establish an optimal model; scanning a spectrum of the traditional Chinese medicine suspension system in an online mode and introducing the obtained spectrum data into the optimal model to predict ingredient contents in the traditional Chinese medicine suspension system to be tested. According to the detection method disclosed by the invention, online analysis of the traditional Chinese medicine suspension system is achieved, and ingredient contents in the traditional Chinese medicine suspension system can be accurately analyzed; the method belongs to an in-situ non-destructive technology and canquickly and safely collect analysis data in real time; a technological process, a mechanism and key control parameters can be deep known, a production technology terminal point can be judged, and convenience in operation is achieved.

Description

technical field [0001] The invention belongs to the field of intelligent manufacturing of traditional Chinese medicines, in particular to the field of online analysis of intelligent manufacturing of traditional Chinese medicines, in particular to a detection method for suspension systems of traditional Chinese medicines. Background technique [0002] The online mid-infrared (MIR) spectroscopy technology adopts Fourier transform infrared technology, and the attenuated total reflection probe is immersed in the liquid to directly measure the MIR region of the substance (3000-650cm -1 ) absorption, real-time tracking of changes in the content of ingredients, can effectively monitor the continuous production process. Online mid-infrared spectroscopy technology has the following advantages: (1) does not destroy samples; (2) has fast detection speed, rich information, and high accuracy; (3) is not affected by solid particles, air bubbles, and temperature; (4) can detect on-line . ...

Claims

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Application Information

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IPC IPC(8): G01N21/3577G01N21/552
CPCG01N21/3577G01N21/552
Inventor 肖伟徐芳芳毕宇安黄文哲王振中徐桂红张欣
Owner JIANGSU KANION PHARMA CO LTD
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