A Method for Measuring Drug Bitterness Based on Bitterness Threshold Concentration

Abstract

The invention relates to a method for measuring molecular bitterness of a medicine on the basis of bitterness threshold (BT) concentration. The method comprises the following steps: preparing a seriesof low-concentration solutions of a standard bitter substance and a to-be-tested monomer; at 37 DEG C, performing typical people taste experiment on the series of low-concentration solutions of the standard bitter substance and the to-be-tested monomer by a 'typical psychophysics minimum limit method'; measuring the number of people tasting bitterness under different concentration, performing outlier removal and calculating the final ratio of people tasting bitterness; and establishing a Wible equation between the obtained people number ratio and different concentration. According to the method, the bitterness threshold concentration is established by utilizing the typical people taste experiment and the typical psychophysics minimum limit method, quantitative index for bitterness evaluation of the medicine is provided, technical support is provided for medicine bitter taste masking, the commercial value of the medicine is exploited, the taking effect of the medicine is improved and remarkable economic and social benefits are achieved.

Description

technical field [0001] The invention relates to medicine, in particular to a method for measuring the bitterness of drug molecules based on the bitterness threshold concentration. Background technique [0002] Drug molecule bitterness is an abstract concept. People's evaluation of the bitterness of the drug itself is mostly expressed through qualitative descriptions, such as unbearable bitterness, a little bitterness, almost no bitterness, etc., lacking the expression of its objective measurement. Most of the existing methods for measuring the bitterness of drug molecules have problems such as inconsistent measurement standards and narrow application ranges. There is no scientific, feasible and standardized testing system, which is very unfavorable for the development of drug taste masking research. Therefore, it is very necessary to use a certain method to measure the bitterness of drug molecules so that it can be expressed with accurate mathematical indicators. [0003] ...

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Problems solved by technology

[0005] Therefore, at present, there is no report on systematically elaborating the measurement method of drug bitterness. The present invention aims to establish a method for measuring drug bitterness based on the bitterness threshold concentration, to provide quantitative indicators for the evaluation of drug bitterness, and to provide It is very necessary to lay the foundation for taste masking research, develop the commercial value of drugs, and improve the effect of taking drugs. So, how to quantitatively detect the bitterness of drug molecules has not been reported publicly so far.

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