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Application of fenofibrate single medicine and combined chemotherapy medicine to preparation of antitumor medicine

A technology of fenofibrate and chemotherapeutic drugs, applied in the field of application of fenofibrate single drug and combined chemotherapeutic drugs in the preparation of anti-tumor drugs, can solve the problems of chemotherapy drug resistance and deficiency, achieve tumor growth inhibition, increase Sensitivity, tumor size reduction effect

Active Publication Date: 2018-07-27
WUHAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide the application of fenofibrate alone or in combination with chemotherapy drugs in the preparation of anti-tumor drugs in order to overcome the deficiencies of anti-tumor drug treatment and the problem of chemotherapy resistance in the prior art

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  • Application of fenofibrate single medicine and combined chemotherapy medicine to preparation of antitumor medicine
  • Application of fenofibrate single medicine and combined chemotherapy medicine to preparation of antitumor medicine
  • Application of fenofibrate single medicine and combined chemotherapy medicine to preparation of antitumor medicine

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Embodiment Construction

[0029] In order to make the present invention easier to understand, specific embodiments of the present invention will be further described below.

[0030] (1) Experimental animals and breeding

[0031] Male 6-8 week-old BALB / C inbred mice (body weight 16-20 g) were purchased from Beijing Huafukang Experimental Animal Center. During the experiment, the mice were kept in the ABSL-3 Animal Experiment Center of the Medical Department of Wuhan University.

[0032] (2) Construction of mouse gastric cancer xenograft tumor model

[0033] 1) Take MGC803 cells growing in the logarithmic phase, digest the cells with 0.25% trypsin, add 10% FBS complete medium to stop the digestion, then make cell suspension with PBS solution, adjust the cell concentration to 3×10 7 individual / mL.

[0034] 2) Take 18 healthy BALB / C nude mice, male, 6-8 weeks old, weighing about 20g, and mix 3×10 6 One piece (0.1mL) of MGC803 gastric cancer cells was subcutaneously injected into the outer thigh of each...

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Abstract

The invention provides application of fenofibrate to preparation of antitumor medicine, in particular to application of fenofibrate to reparation of chemotherapy medicine sensitization medicine. The fenofibrate has the obvious inhibition effect on the tumor growth; the volume of the tumor body is reduced; the tumor weight is reduced; no obvious liver and kidney toxicity and whole body toxic and side effects exist; the obvious cooperated effect is achieved when the fenofibrate is used in a way of being combined with chemotherapy medicine; the sensitivity of the tumor on the chemotherapy medicine can be enhanced; the chemotherapy toxicity cannot be increased by the combined use of the fenofibrate and the chemotherapy medicine; in addition, under the condition of reaching the same tumor inhibition effect, the toxic and side effects of the chemotherapy can be reduced through reducing the consumption of the chemotherapy medicine.

Description

technical field [0001] The invention relates to the technical field of anti-tumor drugs, and specifically discloses the application of fenofibrate single drug and combined chemotherapy drugs in the preparation of anti-tumor drugs. Background technique [0002] Gastric cancer is one of the most common tumors, ranking second in terms of incidence and death in my country. Clinically applied tumor treatment is mainly through surgery, physical therapy, chemotherapy and biological therapy. Chemotherapy is one of the main methods for the treatment of gastric cancer, especially systemic treatment for advanced gastric cancer has played a major role. Chemotherapy resistance is an important reason for the failure of advanced gastric cancer treatment. Therefore, it is of great significance to find new drug treatment methods, improve the sensitivity of chemotherapy drugs, and reverse or reduce the occurrence of chemotherapy resistance for the treatment of gastric cancer. Finding safe, ...

Claims

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Application Information

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IPC IPC(8): A61K31/216A61K33/24A61K31/337A61P35/00
CPCA61K31/216A61K31/337A61K33/24A61K2300/00
Inventor 陈露露周福祥徐会唐蒙涂宁李瑞斌石莹莹厉娜
Owner WUHAN UNIV
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