Ammonia oxidizing bacteria for treatment of acne

A technology of ammonia oxidizing bacteria and Propionibacterium acnes, which is applied in the direction of bacterial medical raw materials, antibacterial drugs, cosmetics, etc.

Pending Publication Date: 2018-08-03
AOBIOME
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition to the need for safe and effective products to prevent and treat inflammatory and non-inflammatory acne lesions, there is a substantial unmet need and commercial opportunity for topical treatments that target excess sebum production

Method used

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  • Ammonia oxidizing bacteria for treatment of acne
  • Ammonia oxidizing bacteria for treatment of acne
  • Ammonia oxidizing bacteria for treatment of acne

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0434] Example 1 : Research on ammonia oxidizing bacteria used in human skin: cosmetic effects, safety, testing and skin metagenomics (Metagenomics)

[0435] A blinded, placebo-controlled study of 24 human volunteers randomized with 4:1 AOB and placebo was conducted. Subjects nitrosomonas suspension (10 9 CFU / ml, 2 times a day, a total of 3x 10 per day 10 CFU) was applied to his face and scalp for one week, and then followed for two weeks after application. Volunteers were instructed to avoid using hair products for one week of AOB application and one week after application, and then return to their usual shampoo use for the third week. Scalp swabs were obtained on day 0 as a baseline control and scalp swabs were obtained on days 1, 3, 8, 14 and 21 to assess the presence / absence of AOB by PCR and 16S rRNA sequencing analysis.

[0436] No serious adverse events were related to the AOB application that lasted for a week, and the product was deemed safe. AOB users reported clear im...

Embodiment 2

[0441] Example 2 : Placebo-controlled single, double-blind, randomized, multi-site cosmetic trial to evaluate the performance and tolerability of cosmetic products in improving the appearance of oily skin, facial pores and other cosmetic parameters in subjects with acne proneness

[0442] Phase 2b study:

[0443] AO+ spray (D23 eutrophic nitrosomonas preparation) treatment showed strong efficacy signals in both Skindex, investigator's global assessment and inflammatory injury count (adult group).

[0444] The AO+ spray formulation used in the test of Example 2 contained 50 mM Na 2 HPO 4 And 2mM MgCl 2 1x 10 in aqueous buffer solution 9 CFU / mL ammonia oxidizing bacteria.

[0445] Randomization (1:1:1:1) of B244 (D23 eutrophic nitrosomonas) in 36 adults (age 18+) with acne vulgaris in 4 weeks (two-week treatment, two-week interval) ) Double-blind placebo controlled dose range (2, 4, 8x 10 9 CFU) research. The study was 80% sure to detect a 30% net improvement in IGA (% subject improve...

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PUM

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Abstract

A method for treating a skin disorder, e.g., acne, e.g. acne vulgaris, in a subject is provided. The method comprises administering, e.g., applying, e.g., topically administering, ammonia oxidizing bacteria, e.g., a preparation comprising ammonia oxidizing bacteria, to a surface of the subject. Preparations comprising ammonia oxidizing bacteria for treating such skin disorder, e.g., acne, e.g. acne vulgaris in a subject are also provided.

Description

[0001] Cross references to related applications [0002] This application is a partial continuation of the international patent application number PCT / US2015 / 025909 filed on April 15, 2015. The international patent application number PCT / US2015 / 025909 requires the Greek patent application number 20140100217 filed on April 15, 2014. U.S. Provisional Application No. 62 / 002084 filed on May 22, 2014, U.S. Provisional Application No. 62 / 012811 filed on June 16, 2014, U.S. Provisional Application No. 62 / 053588 filed on September 22, 2014, and 2015 Priority of Greek Patent Application No. 20150100115 filed on March 13, 2005, the content of which is fully incorporated herein by reference. This application also claims priority for U.S. Provisional Application No. 62 / 188343 filed on July 2, 2015 and U.S. Provisional Application No. 62 / 189105 filed on July 6, 2015. Background of the invention [0003] Beneficial bacteria can be used to inhibit the growth of pathogenic bacteria. Bacteria and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/74A61K35/744A61K35/745A61K35/747A61P17/10
CPCA61Q5/02A61K8/645A61Q5/12A61Q19/10A61K35/74A61K2800/30A61P17/00A61P17/10A61P29/00A61P31/04A61P43/00A61K8/345A61K8/44A61K8/602A61K8/731A61K8/9789A61K2800/87A61K8/362A61K8/442A61K2800/81
Inventor D.R.惠特洛克S.贾马斯L.韦斯
Owner AOBIOME
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