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Polydimethylsiloxane (PDMS) template and preparation method thereof as well as preparation method of array type liquid drop-in-oil structure

An array type and template technology, which is applied in the preparation of PDMS templates and the templates, and the preparation of array type droplet-in-oil structures, can solve the cumbersome preparation process, large amount of reagents, and difficulty in droplet capture, storage and manipulation and other problems, to achieve good effect, reduce preparation cost, and reduce preparation difficulty

Active Publication Date: 2018-08-10
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The existing technology generally completes the preparation of droplets in microfluidic channels. The preparation process is cumbersome and requires the assistance of additional precision instruments. The amount of reagents consumed in the preparation process is too large, and the capture, storage and manipulation of droplets are difficult. Big

Method used

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  • Polydimethylsiloxane (PDMS) template and preparation method thereof as well as preparation method of array type liquid drop-in-oil structure
  • Polydimethylsiloxane (PDMS) template and preparation method thereof as well as preparation method of array type liquid drop-in-oil structure
  • Polydimethylsiloxane (PDMS) template and preparation method thereof as well as preparation method of array type liquid drop-in-oil structure

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Effect test

Embodiment 1

[0048] This embodiment relates to a method for preparing a PDMS template. The overall design idea of ​​the method mainly includes the following steps:

[0049] Step a, etching a cylindrical micropillar array composed of micropillars in the etching area on the surface of the silicon wafer to obtain a micropillar silicon wafer;

[0050] Step b, carrying out hydrophobic treatment on the surface of the obtained micropillar silicon wafer;

[0051] Step c, dripping PDMS material on the etched area where the micropillar array is located and spreading it evenly;

[0052] In step d, the PDMS material is solidified to form a PDMS film, and after the PDMS film is separated from the micropillar silicon wafer, a PDMS template with micropillar through holes is obtained.

[0053] Wherein, in order to further improve the overall use effect, the micropillars contained in the micropillar arrays located in the same area are the same.

[0054] Based on the overall design idea above, the actual ...

Embodiment 2

[0061] This embodiment relates to a preparation method of an array liquid-in-oil droplet structure. The overall design concept of the method mainly includes the following steps:

[0062] Step A, taking a glass sheet and processing it to form a hydrophobic layer on the surface of the glass sheet;

[0063] Step B, sticking the PDMS template of Example 1 on the glass sheet obtained in step A;

[0064] Step C, after plasma treatment, remove the PDMS template to obtain a hydrophilic and hydrophobic glass substrate;

[0065] Step D, after filling reagents into the area corresponding to the through-hole of the microcolumn on the PDMS template of the hydrophilic-hydrophobic glass substrate, adding oil to the area corresponding to the through-hole of the microcolumn to obtain an arrayed liquid-in-oil droplet structure.

[0066] Based on the design idea above, in this embodiment, the steps of the method are specifically described as follows:

[0067] In step A, a glass sheet is taken ...

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Abstract

The invention provides a polydimethylsiloxane (PDMS) template and a preparation method thereof as well as a preparation method of an array type liquid drop-in-oil structure. The preparation method ofthe PDMS template comprises the following steps: a, etching a cylindrical micro-column array, consisting of micro-columns, in an etching area on the surface of a silicon wafer to obtain a micro-columnsilicon wafer; b, carrying out hydrophobic treatment on the surface of the obtained micro-column silicon wafer; c, dropwise adding a PDMS material into the etching area where the micro-column array is located, and uniformly spreading; d, enabling the PDMS material to be solidified so as to form a PDMS thin film, and separating the PDMS thin film from the micro-column silicon wafer to obtain the PDMS template with micro-column through holes. The PDMS template prepared by the preparation method has an array with the micro-column through holes, so that the subsequent preparation of the array type liquid drop-in-oil structure is facilitated, and the preparation difficulty of the array type liquid drop-in-oil structure and the dosage of reagents used in preparation of liquid drop-in-oil are reduced; the PDMS template can be reused.

Description

technical field [0001] The invention relates to the technical field of droplet of micro-volume liquid, in particular to a PDMS template and a method for preparing the template; meanwhile, the invention also relates to a method for preparing an arrayed droplet-in-oil structure by using the PDMS template. Background technique [0002] At present, the most commonly used methods for the generation of micro-volume droplets are active and passive. The active method mainly uses external driving forces such as air pressure, piezoelectricity, microvalve, and magnetic field to achieve droplet generation, and the passive method directly uses microchannels. The geometrical constraints induce deformation of the flow field interface due to increased interfacial instabilities resulting in the generation of droplet arrays. The existing technology generally completes the preparation of droplets in microfluidic channels. The preparation process is cumbersome and requires the assistance of add...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00C12M1/00C12M3/00B81B1/00B81C1/00C12R1/19
CPCB01L3/502707B01L2200/06B01L2200/12B01L2300/0809B01L2300/12B81B1/006B81C1/00087B81C1/00119B81C1/00349C12M23/16
Inventor 巫金波
Owner SHANGHAI UNIV
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