3D bioprinted interbody fusion cage made of HA-PEEK nanocomposite

Abstract

The invention discloses a 3D bioprinted interbody fusion cage made of a HA-PEEK nanocomposite. The 3D bioprinted interbody fusion cage provided by the invention overcomes the technical problem of celldeath since the printing temperature of a scaffold material during 3D printing of an interbody fusion cage is higher than the survival temperature of cells in the prior art. According to the invention, after endothelial cells are printed on the surface of a rotary collector, a first scaffold is assembled on the rotary collector printed with the endothelial cells; then smooth muscle cells are printed on the surface of the first scaffold; then a second scaffold is assembled at the periphery of the first scaffold printed with the smooth muscle cells, and is further printed with the HA-PEEK nanocomposite material; and finally, the rotary collector is put into a cell culture cell for soaking, and then demolding is carried out to obtain the interbody fusion cage. The first scaffold and the second scaffold are prepared in advance by using a 3D printing method; and the pre-preparation manner of two scaffolds can ensure that cells are assembled, printed and implanted after the scaffolds are cooled, layered uniform implantation of cells is realized and the problem of cell death due to high temperature during printing is avoided.

Description

technical field [0001] The invention belongs to the technical field of implanted devices in medical devices, and in particular relates to a 3D bioprinted nano HA-PEEK composite material intervertebral fusion device. Background technique [0002] At present, most of the intervertebral fusion cages used clinically are non-degradable polymer materials such as polyester products and polytetrafluoroethylene. For the replacement of the intervertebral fusion cage, the intervertebral fusion cage made of this material is mainly coated with anticoagulant or thrombosis-inhibiting drugs on the inner surface, which can achieve a better patency effect in the early stage, but the drug is gradually released in the later stage of transplantation. Afterwards, it is easy to form a thrombus and eventually lead to the failure of the graft. [0003] Endothelial cells have anti-thrombosis, inhibition of platelet focus and pathological hyperplasia of smooth muscle, etc., and are considered to be t...

AI Technical Summary

Problems solved by technology

[0005] This application provides a 3D bioprinted nano-HA-PEEK composite intervertebral fusion device, which solves the problem that the printing temperature of the existing scaffold material is higher than the survival temperature of the cells in the process of printing the intervertebral fusion device using 3D technology. technical problems of death