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High-strength gradient full-absorption artificial ligament and preparation method thereof

An artificial ligament, full absorption technology, applied in the field of biomedical textile preparation, to achieve the effects of high-strength mechanical properties, avoidance of secondary weaving and dense pore structure

Active Publication Date: 2018-08-24
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to prepare a high-strength gradient fully absorbable artificial ligament, which has excellent mechanical properties and can be degraded by gradient

Method used

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  • High-strength gradient full-absorption artificial ligament and preparation method thereof
  • High-strength gradient full-absorption artificial ligament and preparation method thereof
  • High-strength gradient full-absorption artificial ligament and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A preparation method of a high-strength gradient fully absorbable artificial ligament:

[0034] Step 1: Determine the yarn and ligament structure parameters

[0035]Fiber A, fiber B, and fiber C use PLA fiber, PCL fiber, and P4HB fiber respectively. The diameter of a single yarn is 0.4mm, and the complete degradation time is 12 months; the number of fibers in the cortex 3 is 40, of which 4 are PLA fibers, 14 PCL fibers and 22 P4HB fibers, the number of core yarns 5 in the core layer 4 is 10; 55%, which is schematically shown as Figure 3-1 shown.

[0036] Step 2: Preparation of Gradient Degraded Yarn

[0037] Combined and twisted 4 PLA fibers, 14 PCL fibers and 22 P4HB fibers through the combined yarn forming process with a twisting speed of 3000r / min and a twist angle of 20° to prepare a single yarn That is, the skin layer 3 of the skin-core double-layer tubular structure; the core layer 4 of the skin-core double-layer tubular structure with uniform tension is obta...

Embodiment 2

[0043] A preparation method of a high-strength gradient fully absorbable artificial ligament:

[0044] Step 1: Determine the yarn and ligament structure parameters

[0045] Fiber A, fiber B, and fiber C use PLA fiber, PCL fiber, and P4HB fiber respectively. The diameter of a single yarn is 0.8mm, and the complete degradation time is 13 months; the number of fibers in the cortex 3 is 80, of which 16 are PLA fibers, 16 PCL fibers and 48 P4HB fibers, the number of core yarns 5 in the core layer 4 is 30; 60%, the schematic diagram is as Figure 3-2 shown.

[0046] Step 2: Preparation of Gradient Degraded Yarn

[0047] 16 PLA fibers, 16 PCL fibers and 48 P4HB fibers were combined and twisted through the composite yarn forming process of the covered yarn method. The twisting speed was 4000r / min, and the twist angle was 40°. The prepared single yarn That is, the cortex 3 of the skin-core double-layer tubular structure; the core layer 4 of the skin-core double-layer tubular struct...

Embodiment 3

[0053] A preparation method of a high-strength gradient fully absorbable artificial ligament:

[0054] Step 1: Determine the yarn and ligament structure parameters

[0055] Fiber A, fiber B, and fiber C use PLA fiber, PCL fiber, and P4HB fiber respectively. The diameter of a single yarn is 1mm, and the complete degradation time is 15 months; the number of fibers in the cortex 3 is 100, of which 10 are PLA fibers, 10 PCL fibers and 80 P4HB fibers, the number of core yarns 5 in the core layer 4 is 50; 80%, the schematic diagram is as Figure 3-3 shown.

[0056] Step 2: Preparation of Gradient Degraded Yarn

[0057] The single yarn prepared by combining and twisting 10 PLA ​​fibers, 10 PCL fibers and 80 P4HB fibers through the composite yarn forming process by wrapping yarn method, the twisting speed is 5000r / min, and the twist angle is 60° That is, the skin layer 3 of the skin-core double-layer tubular structure; the core layer 4 of the skin-core double-layer tubular structu...

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Abstract

The invention discloses a high-strength gradient full-absorption artificial ligament and a preparation method of the high-strength gradient full-absorption artificial ligament. The artificial ligamentcomprises an articular cavity free section and marrow channel woven sections at the two ends of the articular cavity free section, wherein the marrow channel woven sections are of sheath-core double-layer tube-shaped structures, and the sheath-core double-layer tube-shaped structures are composed of sheath layers and core layers. The preparation method comprises the following step: preparing themarrow channel woven sections of the sheath-core double-layer tube-shaped structures by adopting a weaving, knitting or braiding integrated forming technology, wherein weft yarns are not arranged at the articular cavity free section, namely, parallel free yarns not participating in weaving are adopted. The adopted yarns are formed by twisting and compounding fibers with different degrading periodsat the specific ratio, after implantation, a three-dimensional spiral through porous channel can be constructed through gradient degrading, thus the oriented growth of host cells is induced, and meanwhile, the requirement for the mechanical property needed during the tendon-bone healing process is met.

Description

technical field [0001] The invention relates to a high-strength gradient fully-absorbable artificial ligament for treating anterior cruciate ligament injuries and a preparation method thereof, especially a high-strength gradient fully-absorbable artificial ligament prepared by integral molding technology, which belongs to biomedical textiles Preparation technology field. Background technique [0002] The anterior cruciate ligament is located in the knee joint, connecting the femur and tibia, and is an important structure to maintain the stability of the knee joint. Due to its special structure and location, it is easily damaged in daily activities and sports, and its self-healing ability is poor, which affects joint performance. At present, the main method for clinical treatment of ligament injury is surgical reconstruction, and commonly used grafts include autologous tendon, allogeneic tendon and artificial ligament. Among them, autologous transplantation has no immune re...

Claims

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Application Information

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IPC IPC(8): A61L27/58A61L27/40D02G3/04D02G3/36D02G3/38D02G3/44
CPCA61L27/58A61L2430/10D02G3/04D02G3/36D02G3/38D02G3/448
Inventor 王璐谢晓静林婧劳继红高晶王富军关国平李彦李超婧张倩刘来俊
Owner DONGHUA UNIV
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