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Application of NF-L in neurosyphilis cerebrospinal fluid detection

A technology of NF-L and cerebrospinal fluid, applied in the field of biomedicine, can solve the problems of unclear cell molecular mechanism and low specificity

Active Publication Date: 2018-08-24
BEIJING DITAN HOSPITAL CAPITAL MEDICAL UNIV
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Problems solved by technology

[0018] According to reports, there are many markers that can reflect central nervous system damage, such as β-amyloid precursor protein and β-amyloid protein, myelin basic protein, neuron-specific enolase, microtubule-associated protein tau, etc. There are also some changes in syphilis, but they all have problems such as lack of specificity
Neurofilament protein is speculated to be related to various nervous system diseases, but its cellular and molecular mechanism is still unclear

Method used

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  • Application of NF-L in neurosyphilis cerebrospinal fluid detection
  • Application of NF-L in neurosyphilis cerebrospinal fluid detection
  • Application of NF-L in neurosyphilis cerebrospinal fluid detection

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Embodiment

[0055] 1. General clinical data of the patient

[0056] A total of 92 patients were enrolled in this study. According to WS 273-2007 syphilis diagnostic criteria, he was diagnosed with symptomatic neurosyphilis, asymptomatic neurosyphilis and latent syphilis. Among them, there were 23 cases in the symptomatic neurosyphilis group; 51 cases in the asymptomatic neurosyphilis group; and 18 cases in the latent syphilis control group.

[0057] All patients in the symptomatic neurosyphilis group were positive for plasma TPPA; 1 patient with plasma RPR titer 1:1, 2 patients with 1:4, 2 patients with 1:8, 3 patients with 1:16, 4 patients with 1:32 , 4 patients at 1:64, 2 patients at 1:128, and 5 patients at 1:256. CSF TPPA was positive in 23 cases; CSF RPR titer was negative in 1 case, 1:1 in 6 cases, 1:2 in 3 cases, 1:4 in 5 cases, 1:8 in 3 cases, 1:16 in 4 cases, 1 : 1 case of 32 patients. The median of cerebrospinal fluid protein was 62.3mg / dl, the maximum was 191.6mg / dl, and th...

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Abstract

The invention relates to application of NF-L in neurosyphilis cerebrospinal fluid detection, and specifically provides a neurosyphilis detection kit which comprises a detection reagent for detecting level of neurosyphilis cerebrospinal fluid NF-L. The invention further provides application of a first detection reagent for detecting neurosyphilis cerebrospinal fluid NF-L in preparing the neurosyphilis detection kit. The kit can be used for early diagnosis, typing and staging, therapeutic evaluation and / or prognosis evaluation for neurosyphilis, and has the advantages of being high in reliability, high in sensitivity and the like.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of NF-L in the detection of neurosyphilis cerebrospinal fluid. Background technique [0002] Intermediate filaments (IFs) are one of the three skeleton proteins that make up the axonal complex network system of nerve cells. The intermediate fibers have a fixed effect on the nucleus, provide mechanical strength to the cells, participate in cell connections, and play a role in the transport of intracellular substances. , Participate in cell division activities, participate in information transmission activities, etc. The intermediate fiber is a hollow fiber structure with a diameter of 10nm, which is mainly divided into six categories such as neurofilament protein. Neurofilament (NF) is only expressed in nerve cells, including neurofilament light chain (Neurofilament-Light, NF-L), neurofilament medium chain (Neurofilament-Medium, NF-M), neurofilament heavy chai...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68G01N33/577
CPCG01N33/577G01N33/6863G01N2333/715G01N2800/2871G01N2800/2857
Inventor 伦文辉许东梅
Owner BEIJING DITAN HOSPITAL CAPITAL MEDICAL UNIV
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