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Radix paeoniae rubra terpene glycoside composition with function of anti-myocardial ischemia and preparation method thereof

A technology of anti-myocardial ischemia and paeonolin, which is applied in the direction of medical preparations containing active ingredients, drug combinations, cardiovascular system diseases, etc., can solve unfavorable research and application, unfavorable anti-myocardial ischemia, and insufficient material basis clarification and other issues

Inactive Publication Date: 2018-08-28
HUANGSHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Radix Paeoniae Radix Paeoniae Rubra is usually used in the form of water decoction. Because the material basis is not clear enough, it is not conducive to the research and application of modern Chinese medicine preparations, and it is also not conducive to effectively exerting its anti-myocardial ischemia effect.

Method used

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  • Radix paeoniae rubra terpene glycoside composition with function of anti-myocardial ischemia and preparation method thereof
  • Radix paeoniae rubra terpene glycoside composition with function of anti-myocardial ischemia and preparation method thereof
  • Radix paeoniae rubra terpene glycoside composition with function of anti-myocardial ischemia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1 injection

[0025] The paeoniflorin composition described in this example includes: 50.0 wt% of paeoniflorin, 25.0 wt% of paeoniflorin, 15.0 wt% of benzoyl paeoniflorin, and 10.0 wt% of oxidized paeoniflorin.

[0026] Dissolve the selected amount of the above-mentioned paeony glucoside composition with water for injection, slowly add sodium bicarbonate in portions and keep stirring, when no bubbles are generated on the liquid surface, add sodium metabisulfite to dissolve, add water for injection to the full amount; then use pH acidity The pH value of the medicinal solution measured by the meter should be 5.5-8.0. If it is not within this range, sodium bisulfate can be used to adjust it; take the prepared medicinal solution and filter it with a No. 3 vertical fusing glass filter until it is clear, fill and seal the ampoule, 100 ° C, 30 It can be sterilized in minutes.

Embodiment 2

[0027] Embodiment 2 capsules

[0028] The paeoniflorin composition described in this example includes: 50.0 wt% of paeoniflorin, 5.0 wt% of paeoniflorin, 30.0 wt% of benzoyl paeoniflorin, and 15.0 wt% of oxidized paeoniflorin.

[0029] Add a selected amount of the paeony glucoside composition to an appropriate amount of starch and mix to form granules, dry, mix evenly, and pack into capsules to obtain capsules.

Embodiment 3

[0030] Embodiment 3 capsules

[0031] The paeoniflorin composition described in this example comprises: 50.0 wt% of paeoniflorin, 30.0 wt% of paeoniflorin, 19.0 wt% of benzoyl paeoniflorin, and 1.0 wt% of oxidized paeoniflorin.

[0032] Adding a selected amount of the above-mentioned paeillone glucoside composition to an appropriate amount of dextrin and mixing it to form granules, drying, mixing evenly, and packing into capsules to obtain capsules.

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PUM

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Abstract

The invention relates to the technical field of pharmaceutical preparations, in particular to a radix paeoniae rubra terpene glycoside composition with a function of anti-myocardial ischemia, and further discloses a preparation method and application of the composition. The radix paeoniae rubra terpene glycoside composition with the function of the anti-myocardial ischemia takes paeoniflorin, albiflorin std, benzoylpaeoniflorin and oxypaeoniflorin as effective constituents, and an experimental result demonstrates that the radix paeoniae rubra terpene glycoside composition can restrain the hypoxia damage of H9C2 myocardial cells induced by sodium hydrosulfite, and can be widely applied to the preparation of medicine used for preventing and treating myocardial ischemia diseases.

Description

technical field [0001] The technical field of pharmaceutical preparations of the present invention specifically relates to a paeonolin composition with anti-myocardial ischemia effect, and further discloses its preparation method and application. Background technique [0002] Myocardial ischemia refers to a pathological state in which the blood perfusion of the heart is reduced, resulting in reduced oxygen supply to the heart, abnormal myocardial energy metabolism, and failure to support the normal work of the heart, which can easily lead to dysfunction, tissue damage, and myocardial necrosis. , and even lead to sudden cardiac death. Since the energy required for heart activity is almost entirely provided by aerobic metabolism, even at rest, the blood oxygen uptake rate of the myocardium is very high (about 70%). Supply and demand are relatively constant to keep the heart working properly. When some reason leads to an imbalance between the supply and demand of myocardial b...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P9/10
CPCA61K31/7048A61K2300/00
Inventor 柯仲成程小玲周权李长江
Owner HUANGSHAN UNIV
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