Key vitamin D metabolism related genetic polymorphism combinations and uses

A technology of vitamins and genotypes, applied in biochemical equipment and methods, microbial measurement/testing, etc., can solve problems such as differences in vitamin D supplementation effects

Active Publication Date: 2018-08-31
SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
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Problems solved by technology

[0005] Clinically, it has been found that different indiv

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  • Key vitamin D metabolism related genetic polymorphism combinations and uses
  • Key vitamin D metabolism related genetic polymorphism combinations and uses
  • Key vitamin D metabolism related genetic polymorphism combinations and uses

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Experimental program
Comparison scheme
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Embodiment Construction

[0090] The present inventors have found that genetic variation of different individuals has a significant effect on the level of 25(OH)D in vivo after vitamin D supplementation, thereby completing the present invention.

[0091] Specifically, the purpose of the present invention is to determine whether an individual is suitable for high-dose vitamin D supplementation, and when to take a subsequent high-dose vitamin D supplement after high-dose vitamin D supplementation. In the present invention, the high dose of vitamin D is usually 300,000 international units (IU) of vitamin per dose or per session.

[0092] The present invention finds that whether an individual is suitable for high-dose vitamin D supplementation and when to take a subsequent high-dose vitamin D after high-dose vitamin D supplementation is related to the total 25(OH) in blood of the individual D level, age, sex, body weight, and several genetic variation sites are related. These genetic variation loci includ...

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Abstract

The invention relates to key vitamin D metabolism related genetic polymorphism combinations and uses, and specifically provides a detection kit. The detection kit includes (1) a reagent for detectingtotal 25 (OH) D3 levels in the blood of an object; (2) a reagent for detecting the DBP haplotype of the object; (3) a reagent for detecting the genetic variation loci of the object, the genetic variation loci being as follows: rs10741657, rs7968585, rs12512631, rs2296241, rs6013897, rs2209314 and rs4809958; and (4) appliances for carrying out various tests, including but not limited to disposableblood collection appliances and containers, wherein the step (3) and (4) are optional. The detection kit can be used for analyzing or judging whether the object is vitamin D deficiency, and used for determining the medicine taking scheme of the object of taking 300,000 international units of vitamin D.

Description

technical field [0001] The present invention relates to key vitamin D metabolism-related gene genetic polymorphism combination and application. Background technique [0002] Vitamin D, a sterol derivative, is a fat-soluble vitamin that has anti-rickets effects. There are five compounds of vitamin D, vitamin D2 and vitamin D3 are more closely related to health, they have the following three characteristics: it exists in some natural foods; the human body stores 7-dehydrocholesterol produced from cholesterol under the skin, which is affected by After ultraviolet radiation, it can be converted into vitamin D3. [0003] Vitamin D obtained from food is absorbed with fat. When vitamin D is transported to the liver, it acts on the monooxygenase system in microsomes, and its 25th position is hydroxylated to form 25(OH)D. Other tissues outside the liver can also absorb vitamin D and 25(OH)D. [0004] Vitamin D deficiency can lead to rickets in children and rickets in adults. Rick...

Claims

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Application Information

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IPC IPC(8): C12Q1/6883
CPCC12Q1/6883C12Q2600/156
Inventor 王慧陈培战段晓华
Owner SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
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